Evidence map›Paper›PMID 25126410›Full record

ArticleCell & bioscience2014

Ring finger protein 39 genetic variants associate with HIV-1 plasma viral loads and its replication in cell culture.

Ying-Ju Lin, Chia-Yen Chen, Kuan-Teh Jeang, Xiang Liu, Jen-Hsien Wang, Chien-Hui Hung, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Ying-Ju Lin *Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Chia-Yen Chen *Viral Biochemistry Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Kuan-Teh JeangMolecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Xiang LiuMolecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Jen-Hsien WangSection of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
Chien-Hui HungGraduate Institute of Clinical Medical Science, Chang-Gung University, Chiayi, Taiwan.
Hsinyi TsangThe Laboratory of Molecular Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Ting-Hsu LinGenetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Chiu-Chu LiaoGenetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Shao-Mei HuangGenetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Cheng-Wen LinDepartment of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan.
Mao-Wang HoSection of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
Wen-Kuei ChienBiostatistics Center, China Medical University, Taichung, Taiwan.
Jin-Hua ChenBiostatistics Center, China Medical University, Taichung, Taiwan.
Tsung-Jung HoSchool of Chinese Medicine, China Medical University, Taichung, Taiwan.
Fuu-Jen TsaiGenetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
China Medical University Hospital · TWChina Medical University · TWNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USAsia University · TWChang Gung University · TWChina Medical University Beigang Hospital · TWTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe human immunodeficiency virus (HIV-1) exploits host proteins to complete its life cycle. Genome-wide siRNA approaches suggested that host proteins affect HIV-1 replication. However, the results barely overlapped. RING finger protein 39 (RNF39) has been identified from genome-wide association studies. However, its function during HIV-1 replication remains unclear. METHODS AND

resultsWe investigated the relationship between common RNF39 genetic variants and HIV-1 viral loads. The effect of RNF39 protein knockdown or overexpression on HIV-1 replication was then investigated in different cell lines. Two genetic variants were associated with HIV-1 viral loads. Patients with the ht1-GG/GG haplotype presented lower RNF39 expression levels and lower HIV-1 viral load. RNF39 knockdown inhibited HIV-1 expression.

conclusionsRNF39 protein may be involved in HIV-1 replication as observed in genetic studies on patients with HIV-1 and in in vitro cell cultures.

Indexed as

HIV-1 viral loadRNF39Single nucleotide polymorphismViral replication

Identifiers

PMID25126410
PMCPMC4131809
OpenAlexW2166274687

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.