Evidence map›Paper›PMID 25126189›Full record

ArticleInternational journal of clinical and experimental medicine2014

Gene profiling analysis for patients with oral verrucous carcinoma and oral squamous cell carcinoma.

Yue-Hong Wang, Xin Tian, Ou-Sheng Liu, Xiao-Dan Fang, Hong-Zhi Quan, Shang Xie, Shan Gao, Zhan-Gui Tang

Abstract read
In one paragraph

Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Overexpression ofOncology letters · 2020
    Article
  7. Article
  8. Article
  9. Acral Verrucous Carcinoma.Current health sciences journal
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Yue-Hong WangDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital and School of Stomatology, Central South University Changsha 410078, China.
Xin TianSection of Nephrology, School of Medicine, Yale University 1 Gilbert Street, TAC #S360, New Haven, CT, 06510, USA.
Ou-Sheng LiuDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital and School of Stomatology, Central South University Changsha 410078, China.
Xiao-Dan FangDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital and School of Stomatology, Central South University Changsha 410078, China.
Hong-Zhi QuanDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital and School of Stomatology, Central South University Changsha 410078, China.
Shang XieDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital and School of Stomatology, Central South University Changsha 410078, China.
Shan GaoThe Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology and Genetics, Aarhus University 8000 Aarhus C, Denmark ; Kunshan RNAi Institute Kunshan, Jiangsu 215300, China.
Zhan-Gui TangDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital and School of Stomatology, Central South University Changsha 410078, China.
Central South University · CNAarhus University · DKYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral verrucous carcinoma (OVC) is one malignant tumor which was carved out from the oral squamous cell carcinoma (OSCC). However, the clinical and pathological features as well as the treatment strategies of OVC are different from OSCC. Here, global transcript abundance of tumor tissues from five patients with primary OVC and six patients with primary OSCC including their matched adjacently normal oral mucosa were profiled using the Affymetrix HGU133 Plus 2.0. Ingenuity Systems IPA software was used to analyse the gene function and biological pathways. There were 109 differentially expressed genes (more than 2-fold) between OVC and the adjacently normal tissue, among them 66 were up-regulated and 43 were down-regulated; 1172 differentially expressed genes (2-fold) between OSCC and the adjacently normal tissue, among them 608 were up-regulated and 564 were down-regulated. There were 39 common differentially expressed genes in OVC and OSCC compared with their matched normal oral mucosa, among them 22 up-regulated and 17 down-regulated, and 8 of them different between OVC and OSCC. In addition, the gene expression profile was further validated by quantitative real-time PCR (Q-RT-PCR) analysis for four of those 39 selected genes.

Indexed as

biological pathwaysexpression profileoral squamous cell carcinomaOral verrucous carcinomaquantitative real-time PCR

Identifiers

PMID25126189
PMCPMC4132153
OpenAlexW2222723229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.