ReviewFrontiers in plant science2014
Unraveling plant hormone signaling through the use of small molecules.
Review in Frontiers in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Triphenylphosphonium is an effective targeting moiety for plant mitochondria.The New phytologist · 2025Article
- Structural requirements of KAI2 ligands for activation of signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Perspectives in Plant Abiotic Stress Signaling.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Plant growth promotion by the interaction of a novel synthetic small molecule with GA-DELLA function.Plant direct · 2022Article
- A highly efficient auxin-producing bacterial strain and its effect on plant growth.Journal, genetic engineering & biotechnology · 2021Article
- Advances in Synthetic Fluorescent Probe Labeling for Live-Cell Imaging in Plants.Plant & cell physiology · 2021Review
- Fluorescent biosensors illuminating plant hormone research.Plant physiology · 2021Review
- Sensors for the quantification, localization and analysis of the dynamics of plant hormones.The Plant journal : for cell and molecular biology · 2021Review
- Efficient Mimics for Elucidating Zaxinone Biology and Promoting Agricultural Applications.Molecular plant · 2020Article
- Article
- Emerging strategies for the identification of protein-metabolite interactions.Journal of experimental botany · 2019Article
- Review
- Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant development.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Screening and identification of a non-peptide antagonist for the peptide hormone receptor inCommunications biology · 2019Article
- A rationally designed JAZ subtype-selective agonist of jasmonate perception.Nature communications · 2018Article
- Auxin signaling: a big question to be addressed by small molecules.Journal of experimental botany · 2018Review
- What Has Been Seen Cannot Be Unseen-Detecting Auxin In Vivo.International journal of molecular sciences · 2017Review
- Effects of Polychlorinated Biphenyls (PCBs) and Their Hydroxylated Metabolites (OH-PCBs) on Arabidopsis thaliana.Environmental science & technology · 2017Article
- Plant Chemical Genetics: From Phenotype-Based Screens to Synthetic Biology.Plant physiology · 2017Review
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants have acquired the capacity to grow continuously and adjust their morphology in response to endogenous and external signals, leading to a high architectural plasticity. The dynamic and differential distribution of phytohormones is an essential factor in these developmental changes. Phytohormone perception is a fast but complex process modulating specific developmental reprogramming. In recent years, chemical genomics or the use of small molecules to modulate target protein function has emerged as a powerful strategy to study complex biological processes in plants such as hormone signaling. Small molecules can be applied in a conditional, dose-dependent and reversible manner, with the advantage of circumventing the limitations of lethality and functional redundancy inherent to traditional mutant screens. High-throughput screening of diverse chemical libraries has led to the identification of bioactive molecules able to induce plant hormone-related phenotypes. Characterization of the cognate targets and pathways of those molecules has allowed the identification of novel regulatory components, providing new insights into the molecular mechanisms of plant hormone signaling. An extensive structure-activity relationship (SAR) analysis of the natural phytohormones, their designed synthetic analogs and newly identified bioactive molecules has led to the determination of the structural requirements essential for their bioactivity. In this review, we will summarize the so far identified small molecules and their structural variants targeting specific phytohormone signaling pathways. We will highlight how the SAR analyses have enabled better interrogation of the molecular mechanisms of phytohormone responses. Finally, we will discuss how labeled/tagged hormone analogs can be exploited, as compelling tools to better understand hormone signaling and transport mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.