ArticleClinical medicine insights. Arthritis and musculoskeletal disorders2014
Incidence and risk of infection in egyptian patients with systemic lupus erythematosus.
Article in Clinical medicine insights. Arthritis and musculoskeletal disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 22 citations in OpenAlex.
- Retrospective analysis of systemic lupus erythematosus patients with latent tuberculosis infection: A 5-year follow-up study.Journal of clinical tuberculosis and other mycobacterial diseases · 2025Article
- Article
- Evaluation of serum presepsin, procalcitonin, copeptin, and high-sensitivity C-reactive protein for differentiating bacterial infection from disease activity in Egyptian patients with systemic lupus erythematosus.Clinical rheumatology · 2021Observational
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundInfection in systemic lupus erythematosus (SLE) is common and is one of the leading causes of morbidity and mortality.
objectiveTo study the risk and occurrence of infection in Egyptian SLE patients and to determine its characteristics.
methodsA total of 200 SLE patients were followed up for 1 year at monthly intervals, undergoing clinical and laboratory evaluation. Disease activity was assessed by SLE disease activity measurement (SLAM) score. Infections were diagnosed on basis of clinical findings, medical opinion, positive blood and urine cultures, Gram stain results, and specific serological assays as measurement of CMV and EBV antibodies.
resultsA total of 55% of patients developed infection, 45% had one infection, and the rest had multiple infection episodes. Total number of infections was 233 infections/year, 47.2% were major and 52.8% were minor infections. Urinary tract was the most commonly involved site with bacterial infection being the commonest isolated organism (46.4%), and E. coli the commonest isolated bacteria (14.2%). There were 51 episodes caused by systemic viral infection (CMV in 25, EBV in 22, HCV in 3, and 1 in HBV).
conclusionThere is a high rate of infection among SLE patients. Disease activity, leukopenia, high CRP level, positive anti-dsDNA, consumed C3, and cyclophosphamide therapy are independent risk factors for infection in SLE.
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