ReviewTransactions of the American Clinical and Climatological Association2014
A novel T cell evasion mechanism in persistent RNA virus infection.
Review in Transactions of the American Clinical and Climatological Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Variation in antiviral immunity and inflammation pathways precedes HIV-1 infection in a high-risk African cohort.The Journal of clinical investigation · 2026Article
- Disseminated Listeria monocytogenes and human pegivirus-1 coinfection.BMC infectious diseases · 2025Article
- Review of human pegivirus: Prevalence, transmission, pathogenesis, and clinical implication.Virulence · 2022Review
- Role of human Pegivirus infections in whole Plasmodium falciparum sporozoite vaccination and controlled human malaria infection in African volunteers.Virology journal · 2021Article
- Discovery of a Novel Simian Pegivirus in Common Marmosets (Microorganisms · 2020Article
- Human Hepegivirus-1: Innocent Traveler, Helpful Symbiote, or Insidious Pathogen?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Belém, Pará, North Region of Brazil.PloS one · 2020Article
- Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection.PLoS pathogens · 2017Article
- Infective respiratory syncytial virus is present in human cord blood samples and most prevalent during winter months.PloS one · 2017Article
- Arteriviruses, Pegiviruses, and Lentiviruses Are Common among Wild African Monkeys.Journal of virology · 2016Article
- Human pegivirus detected in a patient with severe encephalitis using a metagenomic pan-virus array.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Review
- Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection.Science translational medicine · 2015Article
- Tropism of human pegivirus (formerly known as GB virus C/hepatitis G virus) and host immunomodulation: insights into a highly successful viral infection.The Journal of general virology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Hepatitis C virus (HCV) and GB virus type C (GBV-C) are associated with impaired T cell function despite the fact that HCV replicates in hepatocytes and GBV-C in a small proportion of lymphocytes. Recently, we showed that HCV and GBV-C E2-envelope proteins reduce T cell activation via the T cell receptor (TCR) by competing for phosphorylation with a critical kinase in the TCR signaling cascade (Lck). E2 interfered with TCR signaling in E2 expressing cells and in bystander cells. The bystander effect was mediated by virus particles and extracellular microvesicular particles (exosomes). Multiple kinase substrate sites are predicted to reside on viral structural proteins and based on bioinformatic predictions, many RNA virus pathogens may interfere with TCR signaling via a similar mechanism. Identification of T cell inhibitory effects of virus structural proteins may provide novel approaches to enhance the immunogenicity and memory of viral vaccines.
Indexed as
Identifiers
25125715PMC4112695W2258910200What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.