Evidence map›Paper›PMID 25125666›Full record

Trial reportAJNR. American journal of neuroradiology2015

Surpass flow diverter in the treatment of intracranial aneurysms: a prospective multicenter study.

A K Wakhloo, P Lylyk, J de Vries, C Taschner, J Lundquist, A Biondi, M Hartmann, I Szikora, L Pierot, N Sakai and 15 more

Registry-linked trialOpen access · bronzeAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06174727 (Outcomes of Intra-arterial and Endosaccular Flow Diverters for Treatment of Intracranial Aneurysms - International Registry of Intra-arterial and Endosaccular Flow Diverters), which is not on this map. Cited by 81 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 13 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06174727 recruitingnot on this mapstarted 2023, after this paper: background citation

Outcomes of Intra-arterial and Endosaccular Flow Diverters for Treatment of Intracranial Aneurysms - International Registry of Intra-arterial and Endosaccular Flow Diverters (IRF)

TypeobservationalSponsorMontefiore Medical CenterRan2023 to 2027Enrolled5,000ConditionsIntracranial Aneurysm
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 13 syntheses or guidelines pooled it, 168 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Efficacy and safety of flow diverters in posterior circulation aneurysms and comparison with their efficacy in anterior circulation aneurysms: A systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2021
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Trial
  15. Article
  16. Article
  17. Comparison of pipeline embolization device, flow re-direction endoluminal device and surpass flow diverters in the treatment of intracerebral aneurysms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Article
  18. Article
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 18 institutions in 11 countries.

A K WakhlooFrom the Division of Neuroimaging and Intervention (A.K.W.), Departments of Radiology, Neurology, and Neurosurgery ajay.wakhloo@umassmemorial.org.
P LylykDepartment of Neurosurgery (P.L., J.L.), ENERI, Buenos Aires, Argentina.
J de VriesDepartment of Neurosurgery (J.d.V.), Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
C TaschnerDepartment of Neuroradiology (C.T.), University of Freiburg, Freiburg, Germany.
J LundquistDepartment of Neurosurgery (P.L., J.L.), ENERI, Buenos Aires, Argentina.
A BiondiDepartment of Neuroradiology and Endovascular Therapy (A. Biondi), University of Besançon, Besançon, France.
M HartmannDepartment of Neuroradiology (M.H.), Helios Hospital, Berlin, Germany.
I SzikoraNational Institute of Neurosciences (I.S.), Budapest, Hungary.
L PierotDepartment of Neuroradiology (L.P.), Hôpital Maison Blanche, University Hospital of Reims, Reims, France.
N SakaiDepartment of Neurosurgery (N. Sakai, H.I.), Kobe City Medical Center General Hospital, Kobe, Japan.
H ImamuraDepartment of Neurosurgery (N. Sakai, H.I.), Kobe City Medical Center General Hospital, Kobe, Japan.
N SourourDepartment of Neuroradiology (N. Sourour), Hôpital Pitié-Salpetrière, Paris, France.
I RennieDepartment of Neuroradiology (I.R.), The Royal Hospitals, Belfast, Ireland.
M SkalejDepartment of Neuroradiology (M.S., O.B.), Universitātsklinikum Magdeburg, Magdeburg, Germany.
O BeuingDepartment of Neuroradiology (M.S., O.B.), Universitātsklinikum Magdeburg, Magdeburg, Germany.
A BonaféDepartment of Neuroradiology (A. Bonafé), Hôpital Guy de Chauillac, Montpellier, France.
F MeryDepartment of Neurosurgery (F.M.), Pontificia Universidad Católica de Chile, Santiago, Chile.
F TurjmanDepartment of Neuroradiology (F.T.), Hôpital Neurologique, Lyon, France.
P BrouwerDepartment of Neuroradiology (P.B.), Erasmus University Medical Center, Rotterdam, the Netherlands.
E BoccardiDepartment of Neuroradiology (E.B., L.V.), Niguarda Ca' Granda Hospital, Milan, Italy.
L ValvassoriDepartment of Neuroradiology (E.B., L.V.), Niguarda Ca' Granda Hospital, Milan, Italy.
S DerakhshaniDepartment of Neuroradiology (S.D.), Essex Center for Neurological Sciences, Queen's University Hospital, London, United Kingdom.
M W LitzenbergStryker Neurovascular (M.W.L.), Fremont, California.
M J GounisNew England Center for Stroke Research (M.J.G.), University of Massachusetts Medical School, Worcester, Massachusetts.
Surpass Study Group
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITInstituto de Neurologia Y Neurocirugia · CUKobe City Medical Center General Hospital · JPOtto-von-Guericke University Magdeburg · DEUniversity of Massachusetts Chan Medical School · USBelfast Health and Social Care Trust · GBErasmus University Rotterdam · NLHelios Hospital Schwerin · DEHôpital Maison Blanche · FRHôpital Pierre Wertheimer · FROrszágos Idegsebészeti Tudományos Intézet · HUPontificia Universidad Católica de Chile · CLQueen's University · CARadboud University Nijmegen · NLSorbonne Université · FRStryker (United States) · USUniversité de franche-comté · FRUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIncomplete occlusion and recanalization of large and wide-neck brain aneurysms treated by endovascular therapy remains a challenge. We present preliminary clinical and angiographic results of an experimentally optimized Surpass flow diverter for treatment of intracranial aneurysms in a prospective, multicenter, nonrandomized, single-arm study. MATERIALS AND

methodsAt 24 centers, 165 patients with 190 intracranial aneurysms of the anterior and posterior circulations were enrolled. The primary efficacy end point was the percentage of intracranial aneurysms with 100% occlusion on 6-month DSA. The primary safety end point was neurologic death and any stroke through a minimum follow-up of 6 months.

resultsSuccessful flow-diverter delivery was achieved in 161 patients with 186 aneurysms (98%); the mean number of devices used per aneurysm was 1.05. Clinical follow-up (median, 6 months) of 150 patients (93.2%), showed that the primary safety end point occurred in 18 subjects. Permanent neurologic morbidity and mortality were 6% and 2.7%, respectively. Morbidity occurred in 4% and 7.4% of patients treated for aneurysms of the anterior and posterior circulation, respectively. Neurologic death during follow-up was observed in 1.6% and 7.4% of patients with treated intracranial aneurysms of the anterior and posterior circulation, respectively. Ischemic stroke at ≤30 days, SAH at ≤7 days, and intraparenchymal hemorrhage at ≤7 days were encountered in 3.7%, 2.5%, and 2.5% of subjects, respectively. No disabling ischemic strokes at >30 days or SAH at >7 days occurred. New or worsening cranial nerve deficit was observed in 2.7%. Follow-up angiography available in 158 (86.8%) intracranial aneurysms showed 100% occlusion in 75%.

conclusionsClinical outcomes of the Surpass flow diverter in the treatment of intracranial aneurysms show a safety profile that is comparable with that of stent-assisted coil embolization. Angiographic results showed a high rate of intracranial aneurysm occlusion.

Indexed as

Blood Vessel ProsthesisAgedAged, 80 and overCerebral AngiographyEmbolization, TherapeuticFemaleFollow-Up StudiesHumansIntracranial AneurysmMaleMiddle AgedProspective StudiesTreatment Outcome

Identifiers

PMID25125666
PMCPMC7965910
OpenAlexW2110771520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.