Evidence map›Paper›PMID 25125468›Full record

ArticleJournal of Alzheimer's disease : JAD2015

Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.

Haley C Dunn, Rahasson R Ager, David Baglietto-Vargas, David Cheng, Masashi Kitazawa, David H Cribbs, Rodrigo Medeiros

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 92 citations in OpenAlex.

  1. Trial
  2. Nutritional Mushroom Treatment in Meniere's Disease withInternational journal of molecular sciences · 2019
    Trial
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  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Lipoxins AJournal of neuroinflammation · 2024
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Haley C DunnInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
Rahasson R AgerInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
David Baglietto-VargasInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
David ChengInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
Masashi KitazawaDepartment of Molecular and Cell Biology, University of California, Merced, CA, USA.
David H CribbsInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA Department of Neurology, University of California, Irvine, CA, USA.
Rodrigo MedeirosInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
University of California, Irvine · USUniversity of California, Merced · US

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
TISSUE REPOSITORY COREP01AG000538 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 1985 to 2018
$24.8M
NIA NIH HHS AG00538NIA NIH HHS P01 AG000538NIA NIH HHS P50 AG016573NIA NIH HHS P50AG16573
6 · The paper itself

Abstract

The initiation of an inflammatory response is critical to the survival of an organism. However, when inflammation fails to reach resolution, a chronic inflammatory state may occur, potentially leading to bystander tissue damage. Accumulating evidence suggests that chronic inflammation contributes to the progression of Alzheimer's disease (AD), and identifying mechanisms to resolve the pro-inflammatory environment stimulated by AD pathology remains an area of active investigation. Previously, we found that treatment with the pro-resolving mediator aspirin-triggered lipoxin A4 (ATL), improved cognition, reduced Aβ levels, and enhanced microglia phagocytic activity in Tg2576 transgenic AD mice. Here, we evaluated the effect of aging on brain lipoxin A4 (LXA4) levels using non-transgenic and 3xTg-AD mice. Additionally, we investigated the effect of ATL treatment on tau pathology in 3xTg-AD mice. We found that LXA4 levels are reduced with age, a pattern significantly more impacted in 3xTg-AD mice. Moreover, ATL delivery enhanced the cognitive performance of 3xTg-AD mice and reduced Aβ levels, as well as decreased the levels of phosphorylated-tau (p-tau). The decrease in p-tau was due in part to an inhibition of the tau kinases GSK-3β and p38 MAPK. In addition, microglial and astrocyte reactivity was inhibited by ATL treatment. Our results suggest that the inability to resolve the immune response during aging might be an important feature that contributes to AD pathology and cognitive deficits. Furthermore, we demonstrate that activation of LXA4 signaling could serve as a potential therapeutic target for AD-related inflammation and cognitive dysfunction.

Indexed as

Alzheimer DiseaseAnimalsBrainCognitionDisease Models, AnimalDisease ProgressionLipoxinsMiceMice, TransgenicMicrogliaPhosphorylationRecognition, PsychologySignal Transductionlipoxin A4Lipoxins3xTg-ADAgingAlzheimer's diseaseaspirin-triggered lipoxin $A_4$inflammationlipoxinlipoxygenaseresolution

Identifiers

PMID25125468
PMCPMC4319708
OpenAlexW1503881649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.