Evidence map›Paper›PMID 25125349›Full record

ArticleMetabolism: clinical and experimental2014

Effects of a eucaloric reduced-carbohydrate diet on body composition and fat distribution in women with PCOS.

Amy M Goss, Paula C Chandler-Laney, Fernando Ovalle, Laura Lee Goree, Ricardo Azziz, Renee A Desmond, G Wright Bates, Barbara A Gower

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism: clinical and experimental, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 42 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05428566 nacompletednot on this mapstarted 2022, after this paper: background citation

A Comparison of a Pulse-Based Diet and the Therapeutic Lifestyle Changes Diet on Reproductive and Metabolic Parameters in Women with Polycystic Ovary Syndrome

TypeinterventionalSponsorUniversity of JordanRan2022 to 2024Enrolled144ConditionsPolycystic Ovary Syndrome, Metabolic SyndromeArmsPulse-based diet, TLC diet
NCT06545721 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effect and Mechanism Of Weight Cycling on Hyperandrogenemia And Insulin Resistance in Polycystic Ovary Syndrome

TypeinterventionalSponsorPeking Union Medical College HospitalRan2024 to 2026Enrolled425ConditionsPolycystic Ovary SyndromeArmsAdjusting dietary structure + exercise + behavioral intervention, Precision dietary prescription, Standard guideline-based low-energy diet
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  5. Lifestyle changes in women with polycystic ovary syndrome.The Cochrane database of systematic reviews · 2019
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  6. Conceptual Model of Lean Body Mass in Pediatric Inflammatory Bowel Disease.Journal of pediatric gastroenterology and nutrition · 2019
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amy M GossDepartment of Nutrition Sciences, Georgia Regents University, Augusta, GA. Electronic address: amymiski@uab.edu.
Paula C Chandler-LaneyDepartment of Nutrition Sciences, Georgia Regents University, Augusta, GA.
Fernando OvalleDepartment of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Georgia Regents University, Augusta, GA.
Laura Lee GoreeDepartment of Nutrition Sciences, Georgia Regents University, Augusta, GA.
Ricardo AzzizDepartment of Obstetrics & Gynecology, Georgia Regents University, Augusta, GA; Department of Medicine, Georgia Regents University, Augusta, GA.
Renee A DesmondDepartment of Medicine, Division of Preventive Medicine, Georgia Regents University, Augusta, GA.
G Wright BatesDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, Georgia Regents University, Augusta, GA.
Barbara A GowerDepartment of Nutrition Sciences, Georgia Regents University, Augusta, GA.

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
UAB CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE (CCTS) UL1: BPCAUL1RR025777 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2008 to 2011
$22.3M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
UAB Diabetes Research and Training CenterP60DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GARVEY, W TIMOTHY · 2008 to 2012
$8.4M
UAB Obesity Training ProgramT32DK062710 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James O Hill, Brooks C Wingo · 2004 to 2026
$5.5M
Reduced Carbohydrate Diet Intervention for PCOSR01HD054960 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOWER, BARBARA A · 2009 to 2010
$1.4M
NCRR NIH HHS UL1 RR025777NCRR NIH HHS UL1RR025777NICHD NIH HHS R01 HD054960NICHD NIH HHS R01HD054960NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30 DK079626NIDDK NIH HHS P30DK56336NIDDK NIH HHS P60 DK079626NIDDK NIH HHS P60DK079626NIDDK NIH HHS T32 DK062710
6 · The paper itself

Abstract

objectiveTo determine if consumption of a reduced-carbohydrate (CHO) diet would result in preferential loss of adipose tissue under eucaloric conditions, and whether changes in adiposity were associated with changes in postprandial insulin concentration.

methodsIn a crossover-diet intervention, 30 women with PCOS consumed a reduced-CHO diet (41:19:40% energy from CHO:protein:fat) for 8 weeks and a standard diet (55:18:27) for 8 weeks. Body composition by DXA and fat distribution by CT were assessed at baseline and following each diet phase. Insulin AUC was obtained from a solid meal test (SMT) during each diet phase.

resultsParticipants lost 3.7% and 2.2% total fat following the reduced-CHO diet and STD diet, resp. (p<0.05 for difference between diets). The reduced-CHO diet induced a decrease in subcutaneous-abdominal, intra-abdominal, and thigh-intermuscular adipose tissue (-7.1%, -4.6%, and -11.5%, resp.), and the STD diet induced a decrease in total lean mass. Loss of fat mass following the reduced CHO diet arm was associated with lower insulin AUC (p<0.05) during the SMT.

conclusionsIn women with PCOS, consumption of a diet lower in CHO resulted in preferential loss of fat mass from metabolically harmful adipose depots, whereas a diet high in CHO appeared to promote repartitioning of lean mass to fat mass.

Indexed as

Adipose TissueAdultBody CompositionCross-Over StudiesDietary CarbohydratesDiet, ReducingFemaleHumansInsulinPolycystic Ovary SyndromePostprandial PeriodDietary CarbohydratesInsulinIntra-abdominal adipose tissueMacronutrient compositionObesity

Identifiers

PMID25125349
PMCPMC4191914

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.