Trial reportPediatric nephrology (Berlin, Germany)2014
Haemodialysing babies weighing <8 kg with the Newcastle infant dialysis and ultrafiltration system (Nidus): comparison with peritoneal and conventional haemodialysis.
Trial report in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 144 citations in OpenAlex.
- The Japanese clinical practice guideline for acute kidney injury 2016.Clinical and experimental nephrology · 2018Guideline
- Neonatal continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Review
- Continuous kidney replacement therapy in low birth weight and premature neonates-are we entering a new era?Pediatric nephrology (Berlin, Germany) · 2026Article
- Novel extracorporeal therapies in children.Pediatric nephrology (Berlin, Germany) · 2026Article
- Kidney Support Therapy: Recent Advances.Indian journal of pediatrics · 2026Review
- Continuous Kidney Replacement Therapy in Pediatric Intensive Care: A Practical Guide for Clinicians.Indian pediatrics · 2026Review
- Pediatric Dialysis: From Acute Kidney Injury to Chronic Renal Replacement Therapies: Challenges and Perspectives in Resource-Limited Countries.Diseases (Basel, Switzerland) · 2026Review
- Renal replacement therapy in intensive care unit: a narrative review.Annals of intensive care · 2026Review
- Early continuous renal replacement therapy for acute kidney injury in a very low birth weight infant: a case report and literature review.Frontiers in medicine · 2026Article
- Continuous Renal Replacement Therapy in Critically-Ill Term and Preterm Newborns: A Single-Center Study in Belgrade.Children (Basel, Switzerland) · 2025Article
- Continuous renal replacement therapy in extremely low birth weight infants: a series of 5 cases.Italian journal of pediatrics · 2025Article
- The Urgent Need for Hemodialysis and Ultrafiltration Devices Specifically Designed for Neonates.Kidney international reports · 2025Article
- Response to "The Urgent Need for Hemodialysis and Ultrafiltration Devices Specifically Designed for Neonates".Kidney international reports · 2025Article
- The Brophy Kit: A Manual Hemodialysis Device for Neonates.Kidney international reports · 2025Article
- Provision of continuous renal replacement therapy in children in intensive care in Australia and New Zealand.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Peritoneal Dialysis with Rigid Catheters in Children with Acute Kidney Injury: A Single-Centre Experience.Journal of pediatric intensive care · 2024Article
- Programs and processes for advancing pediatric acute kidney support therapy in hospitalized and critically ill children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference.Pediatric nephrology (Berlin, Germany) · 2024Article
- Validation of a low-cost continuous renal replacement therapy dialysate fluid controller for experimental purposes.Intensive care medicine experimental · 2024Article
- New perspectives in pediatric dialysis technologies: the case for neonates and infants with acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2024Article
- A simplified protocol of regional citrate anticoagulation with phosphate-containing solutions in infants and children treated with continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2023Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo compare the efficacy of the Newcastle infant dialysis and ultrafiltration system (Nidus) with peritoneal dialysis (PD) and conventional haemodialysis (HD) in infants weighing <8 kg.
methodsWe compared the urea, creatinine and phosphate clearances, the ultrafiltration precision, and the safety of the Nidus machine with PD in 7 piglets weighing 1-8 kg, in a planned randomised cross-over trial in babies, and in babies for whom no other therapy existed, some of whom later graduated to conventional HD.
resultsTwo babies entered the randomised trial; 1 recovered rapidly on PD, the other remained on the Nidus as PD failed. Additionally, 9 babies were treated on the Nidus on humanitarian grounds: 3 because of failed PD, and 3 with permanent kidney failure later converted to conventional HD. We haemodialysed 10 babies weighing between 1.8 and 5.9 kg for 2,475 h during 354 Nidus sessions without any clinically important incidents, and without detectable haemolysis. Single-lumen vascular access was used with no blood priming of circuits. The urea, creatinine and phosphate clearances using the Nidus were around 1.5 to 2.0 ml/min in piglets and babies, and were consistently higher than PD clearances, which ranged from about 0.2 to 0.8 ml/min (p ≤ 0.0002 for each chemical). Ultrafiltration was achieved to microlitre precision by the Nidus, but varied widely with PD. Fluid removal using conventional HD was imprecise and resulted in some hypovolaemic episodes requiring correction.
conclusionThe Nidus can provide HD in the Pediatric Intensive Care Unit (PICU) and outpatient intermittent HD without blood priming for babies weighing <8 kg, It generates higher dialysis clearances than PD, and delivers more precise ultrafiltration control than either PD or conventional HD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.