Evidence map›Paper›PMID 25125226›Full record

ReviewPediatric nephrology (Berlin, Germany)2015

Viral surveillance and subclinical viral infection in pediatric kidney transplantation.

Jodi M Smith, Vikas R Dharnidharka

Open access · bronzeAbstract readReview
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Long-Term Outcomes of Kidney Transplantation in Children.Pediatric clinics of North America · 2019
    Review
  9. Review
  10. Article
  11. Renal transplantation in infants.Pediatric nephrology (Berlin, Germany) · 2016
    Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jodi M SmithDepartment of Pediatrics, University of Washington, 4800 Sand Point Way NE, OC.9.820, Seattle, WA, 98105, USA, jodi.smith@seattlechildrens.org.
Vikas R Dharnidharka
University of Washington · USWashington University in St. Louis · US

Funding

Subclinical Viral Infection and Renal Allograft InjuryR01DK088914 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI SMITH, JODI M · 2011 to 2015
$1.7M
NIDDK NIH HHS R01 DK088914
6 · The paper itself

Abstract

The more potent immunosuppressive therapy that has successfully reduced the incidence of acute rejection and improved graft outcomes has also resulted in a higher incidence of viral complications. Sensitive molecular methods now allow for the detection of subclinical viral infection, which is increasingly recognized due to the adoption of routine post-transplant viral surveillance protocols. The goal of viral surveillance is the detection of subclinical viral infection that triggers an intervention; one that either prevents progression to viral disease or leads to early diagnosis of viral disease, which is associated with improved outcomes. Knowledge of the epidemiology and natural history of subclinical viral infection and viral disease, as well as patient-specific risk factors, is required to establish the optimal surveillance schedule which achieves the goal of early diagnosis. Evidence that detection of subclinical viral infection can impact viral disease is variable depending on the virus. This review will summarize the current data on the role of viral surveillance for BK virus (BKV), cytomegalovirus (CMV), and the Epstein-Barr virus (EBV) in the pediatric kidney transplant population.

Indexed as

Epidemiological MonitoringImmunocompromised HostKidney TransplantationAsymptomatic InfectionsChildGraft RejectionHumansImmunosuppressive AgentsVirus DiseasesImmunosuppressive Agents

Identifiers

PMID25125226
PMCPMC6192669
OpenAlexW2062021936

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.