ArticleAnatomical record (Hoboken, N.J. : 2007)2014
Expression of myotilin during chicken development.
Article in Anatomical record (Hoboken, N.J. : 2007), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- A computational framework for identifying cytoskeletal genes associated with age-related diseases.Scientific reports · 2025Article
- The Role of Z-disc Proteins in Myopathy and Cardiomyopathy.International journal of molecular sciences · 2021Review
- Characterizing the immune response of chickens to Campylobacter jejuni (Strain A74C).PloS one · 2021Article
- Efficacy of chitosan-based nanoparticle vaccine administered to broiler birds challenged with Salmonella.PloS one · 2020Article
- Recent advances in muscle research.Anatomical record (Hoboken, N.J. : 2007) · 2014Article
- Localization of sarcomeric proteins during myofibril assembly in cultured mouse primary skeletal myotubes.Anatomical record (Hoboken, N.J. : 2007) · 2014Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Several missense mutations in the Z-band protein, myotilin, have been implicated in human muscle diseases such as myofibrillar myopathy, spheroid body myopathy, and distal myopathy. Recently, we have reported the cloning of chicken myotilin cDNA. In this study, we have investigated the expression of myotilin in cross-striated muscles from developing chicken by qRT-PCR and in situ hybridizations. In situ hybridization of embryonic stages shows myotilin gene expression in heart, somites, neural tissue, eyes and otocysts. RT-PCR and qRT-PCR data, together with in situ hybridization results point to a biphasic transcriptional pattern for MYOT gene during early heart development with maximum expression level in the adult. In skeletal muscle, the expression level starts decreasing after embryonic day 20 and declines in the adult skeletal muscles. Western blot assays of myotilin in adult skeletal muscle reveal a decrease in myotilin protein compared with levels in embryonic skeletal muscle. Our results suggest that MYOT gene may undergo transcriptional activation and repression that varies between tissues in developing chicken. We believe this is the first report of the developmental regulation on myotilin expression in non-mammalian species.
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