Evidence map›Paper›PMID 25125097›Full record

Trial reportSurgical endoscopy2015

Neuromuscular blockade improves surgical conditions (NISCO).

Manfred Blobner, Christiane G Frick, Roland B Stäuble, Hubertus Feussner, Stefan J Schaller, Christoph Unterbuchner, Charlotte Lingg, Martina Geisler, Heidrun Fink

7 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 57 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 4 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00895778 nacompletednot on this map

Neuromuscular Blockade Improves Surgical Conditions

TypeinterventionalSponsorTechnical University of MunichRan2009 to 2012Enrolled57ConditionsNeuromuscular BlockadeArmsNeuromuscular blockade with rocuronium and reversal with sugammadex
NCT03179111 nacompletednot on this mapstarted 2017, after this paper: background citation

Evaluation of Low Pressure Pneumoperitoneum in Bariatric Surgery: A Prospective Randomized Study

TypeinterventionalSponsorUniversiti Putra MalaysiaRan2017 to 2018Enrolled94ConditionsSurgical View, Shoulder Tip Pain, Abdominal PainArmsPneumoperitoneum Pressure
NCT03420937 phase4completednot on this mapstarted 2016, after this paper: background citation

Deep Neuromuscular Block During General Anaesthesia in Laparoscopic (and Robotic Laparoscopic) Surgery and Its Potential Benefits for Certain Physiological Parameters in Perioperative Period

TypeinterventionalSponsorUniversity Hospital OlomoucRan2016 to 2017Enrolled138ConditionsObservation of Neuromuscular Block, Complication of Ventilation Therapy, Postoperative RecoveryArmsSugammadex, Neostigmine, Atropin Biotika
NCT04609410 naterminatednot on this mapstarted 2020, after this paper: background citation

Bleeding in Moderate Versus Deep Neuro Muscular Blockade for Laparoscopic Liver Surgery

TypeinterventionalSponsorUniversità Vita-Salute San RaffaeleRan2020 to 2023Enrolled48ConditionsNeuromuscular Blockade, Intraoperative Bleeding, Hepatic CancerArmsNeuromuscular blockade
NCT05689957 nacompletednot on this mapstarted 2020, after this paper: background citation

Evaluation of Surgical Condition During Laparoscopic Gynaecological Surgery in Patient With Moderate vs Deep Neuromuscular Block in Lower Pressure Pneumoperitoneum

TypeinterventionalSponsorUniversiti Sains MalaysiaRan2020 to 2022Enrolled70ConditionsGynecologic Disease, Neuromuscular BlockadeArmsDeep neuromuscular block using intravenous rocuronium induction at 1.2mg/kg and maintainance of 8-12mcg/kg/min for deep neuromuscular block
NCT06517524 completednot on this mapstarted 2023, after this paper: background citation

Effects of Low-pressure Pneumoperitoneum Associated With Deep Pipecuronium-induced Neuromuscular Blockade on Hemodynamic Parameters for High Cardiovascular Risk Patient Undergoing General Anesthesia

TypeobservationalSponsorTamas Vegh, MDRan2023 to 2024Enrolled10ConditionsResidual Neuromuscular Block, Cardiovascular Diseases, Neuromuscular Blockade Monitoring
NCT07706504 narecruitingnot on this mapstarted 2026, after this paper: background citation

Comparison of Two Quantitative Electromyography Monitors for Deep Neuro Muscular Block in Patients Undergoing Abdominal Laparoscopic/Robotic or Thoracic Video-Assisted (VATS) Surgeries

TypeinterventionalSponsorOhio State UniversityRan2026 to 2028Enrolled35ConditionsNeuromuscular BlockadeArmsTetraGraph (Senzime)-Guided Neuromuscular Monitoring (Dominant Hand), TwitchView (Blink)-Guided Neuromuscular Monitoring (Dominant Hand)
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 4 syntheses or guidelines pooled it, 139 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Manfred BlobnerKlinik für Anaesthesiologie, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany.
Christiane G Frick
Roland B Stäuble
Hubertus Feussner
Stefan J Schaller
Christoph Unterbuchner
Charlotte Lingg
Martina Geisler
Heidrun Fink
Technical University of Munich · DEKlinikum rechts der Isar · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe examined the impact of muscle relaxation on surgical conditions and patients' postoperative outcome during elective laparoscopic cholecystectomy under balanced anaesthesia.

methodsAfter approval and consent, 57 anaesthetized patients were randomly assigned to group no neuromuscular blockade (No NMB) and deep neuromuscular blockade (Deep NMB), i.e. no twitch response to train-of-four nerve stimulation. Laparoscopic cholecystectomy was performed using the 4-trocar technique with a CO2-pneumoperitoneum. Surgical conditions were assessed using a Visual Analogue Scale. Movement of diaphragm or abdominal muscles, inadequate visibility, or breathing and coughing against the ventilator were documented as events reflecting inadequate muscle relaxation. Independently, surgeons could request 0.3 mg/kg rocuronium to improve surgical conditions. Workflow variables were obtained as a surrogate of surgical conditions. Data are presented as mean (95 % confidence interval). The trial is registered at ClinicalTrials.gov (NCT00895778).

resultsWhile in 12 of 25 patients of group "No NMB" one or more adverse events impaired the surgical procedure (p < 0.001), only 1 of 25 patients of group "Deep NMB" showed an adverse event. Deep NMB resulted in an absolute risk reduction of 0.44 (0.23-0.65) and a number needed to treat of 2.3 (1.5-4.4), respectively. Surgeons requested 0.3 mg/kg rocuronium in 10 of 25 cases (40 %) of group "No NMB" only. This dose significantly improved surgical conditions by an average 62 of 100 possible points. All further variables did not differ between groups.

conclusionsDeep NMB ameliorates surgical conditions for laparoscopic cholecystectomy by improved visibility and reduction of involuntary movements.

Indexed as

AdultAndrostanolsCholecystectomy, LaparoscopicFemaleHumansMaleMiddle AgedMuscle RelaxationNeuromuscular BlockadeNeuromuscular Nondepolarizing AgentsPostoperative ComplicationsRocuroniumTreatment OutcomeAndrostanolsNeuromuscular Nondepolarizing AgentsRocuronium

Identifiers

PMID25125097
OpenAlexW2037323031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.