ArticleMalaria journal2014
The effects of genetic manipulation, dieldrin treatment and irradiation on the mating competitiveness of male Anopheles arabiensis in field cages.
Article in Malaria journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 40 citations in OpenAlex.
- Effects of different X-ray irradiation dosages on Wolbachia trans-infected and uninfected Aedes aegypti mosquitoes.PLoS neglected tropical diseases · 2026Article
- Effects of chilling, fluorescent dust marking, and X-ray irradiation on the quality of male Anopheles arabiensis for sterile insect technique applications.Scientific reports · 2026Article
- Radiation dose fractionation and its potential hormetic effects on male Glossina palpalis gambiensis (Diptera: Glossinidae): a comparative study of reproductive and flight quality parameters.Parasite (Paris, France) · 2024Article
- The sex pheromone heptacosane enhances the mating competitiveness of sterile Aedes aegypti males.Parasites & vectors · 2023Article
- Sterility ofPathogens (Basel, Switzerland) · 2023Article
- Radiation dose-fractionation in adult Aedes aegypti mosquitoes.Parasite (Paris, France) · 2023Article
- Local adaptation and colonization are potential factors affecting sexual competitiveness and mating choice in Anopheles coluzzii populations.Scientific reports · 2022Article
- Development of the Sterile Insect Technique to control the dengue vector Aedes aegypti (Linnaeus) in Sri Lanka.PloS one · 2022Article
- Review
- Sexual Competitiveness and Induced Egg Sterility byInsects · 2021Article
- The Effect of Radiation on the Gut Bacteriome ofFrontiers in microbiology · 2021Article
- Gamma Irradiation and MaleInsects · 2020Article
- Effect of irradiation on the survival and susceptibility of female Anopheles arabiensis to natural isolates of Plasmodium falciparum.Parasites & vectors · 2020Article
- The role of oxygen depletion and subsequent radioprotective effects during irradiation of mosquito pupae in water.Parasites & vectors · 2020Article
- The efficiency of a new automated mosquito larval counter and its impact on larval survival.Scientific reports · 2019Article
- Article
- A review on the progress of sex-separation techniques for sterile insect technique applications against Anopheles arabiensis.Parasites & vectors · 2018Review
- Impact of irradiation on the reproductive traits of field and laboratory An. arabiensis mosquitoes.Parasites & vectors · 2018Article
- Maintaining Quality of Candidate Strains of Transgenic Mosquitoes for Studies in Containment Facilities in Disease Endemic Countries.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2018Article
- Does mosquito mass-rearing produce an inferior mosquito?Malaria journal · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo enable the release of only sterile male Anopheles arabiensis mosquitoes for the sterile insect technique, the genetic background of a wild-type strain was modified to create a genetic sexing strain ANO IPCL1 that was based on a dieldrin resistance mutation. Secondly, the eggs of ANO IPCL1 require treatment with dieldrin to allow complete elimination of female L1 larvae from the production line. Finally, male mosquito pupae need to be treated with an irradiation dose of 75 Gy for sterilization. The effects of these treatments on the competitiveness of male An. arabiensis were studied.
methodsThe competitiveness of ANO IPCL1 males that were treated either with irradiation or both dieldrin and irradiation, was compared with that of the wild-type strain (An. arabiensis Dongola) at a 1:1 ratio in 5.36 m3 semi-field cages located in a climate-controlled greenhouse. In addition, three irradiated: untreated male ratios were tested in semi-field cages (1:1, 5:1 and 10:1) and their competition for virgin wild-type females was assessed.
resultsThe ANO IPCL1 males were equally competitive as the wild-type males in this semi-field setting. The ANO IPCL1 males irradiated at 75 Gy were approximately half as competitive as the unirradiated wild-type males. ANO IPCL1 males that had been treated with dieldrin as eggs, and irradiated with 75 Gy as pupae were slightly more competitive than males that were only irradiated. Ratios of 1:1, 5:1 and 10:1 irradiated ANO IPCL1 males: untreated wild-type males resulted in 31, 66 and 81% induced sterility in the female cage population, respectively.
conclusionsAn irradiation dose of 75 Gy reduced the competitiveness of male ANO IPCL1 significantly and will need to be compensated by releasing higher numbers of sterile males in the field. However, the dieldrin treatment used to eliminate females appears to have an unexpected radioprotectant effect, however the mechanism is not understood. A sterile to wild-type ratio of 10:1 effectively reduced the population's fertility under the experimental field cage conditions, but further studies in the field will be needed to confirm the efficiency of sterile ANO IPCL1 males when competing against wild males for wild females.
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