ArticleBMC genomics2014
Expression quantitative trait loci infer the regulation of isoflavone accumulation in soybean (Glycine max L. Merr.) seed.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Joint genetic control of isoflavones and soyasaponins revealed by mGWAS, genomic prediction, and SHAP-guided allele stacking.Scientific reports · 2026Article
- Heat shock protein 70 is associated with duration of cell proliferation in early pod development of soybean.Communications biology · 2024Article
- Molecular mechanisms underpinning quantitative resistance toFrontiers in plant science · 2023Article
- Medicinal Potential of Isoflavonoids: Polyphenols That May Cure Diabetes.Molecules (Basel, Switzerland) · 2020Review
- Xylem systems genetics analysis reveals a key regulator of lignin biosynthesis inGenome research · 2020Article
- Identification of Loci and Candidate Genes Analyses for Tocopherol Concentration of Soybean Seed.Frontiers in plant science · 2020Article
- Fine-mapping of QTLs for individual and total isoflavone content in soybean (Glycine max L.) using a high-density genetic map.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Quantitative Trait Transcripts Mapping Coupled with Expression Quantitative Trait Loci Mapping Reveal the Molecular Network Regulating the Apetalous Characteristic inFrontiers in plant science · 2018Article
- Quantitative trait loci from identification to exploitation for crop improvement.Plant cell reports · 2017Review
- eQTLs Regulating Transcript Variations Associated with Rapid Internode Elongation in Deepwater Rice.Frontiers in plant science · 2017Article
- Detecting the QTL-allele system of seed isoflavone content in Chinese soybean landrace population for optimal cross design and gene system exploration.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Exploiting Phenylpropanoid Derivatives to Enhance the Nutraceutical Values of Cereals and Legumes.Frontiers in plant science · 2016Review
- QTLomics in Soybean: A Way Forward for Translational Genomics and Breeding.Frontiers in plant science · 2016Review
- Expanding Omics Resources for Improvement of Soybean Seed Composition Traits.Frontiers in plant science · 2015Review
- Overexpression of Soybean Isoflavone Reductase (GmIFR) Enhances Resistance to Phytophthora sojae in Soybean.Frontiers in plant science · 2015Article
- Mapping isoflavone QTL with main, epistatic and QTL × environment effects in recombinant inbred lines of soybean.PloS one · 2015Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMapping expression quantitative trait loci (eQTL) of targeted genes represents a powerful and widely adopted approach to identify putative regulatory variants. Linking regulation differences to specific genes might assist in the identification of networks and interactions. The objective of this study is to identify eQTL underlying expression of four gene families encoding isoflavone synthetic enzymes involved in the phenylpropanoid pathway, which are phenylalanine ammonia-lyase (PAL; EC 4.3.1.5), chalcone synthase (CHS; EC 2.3.1.74), 2-hydroxyisoflavanone synthase (IFS; EC1.14.13.136) and flavanone 3-hydroxylase (F3H; EC 1.14.11.9). A population of 130 recombinant inbred lines (F5:11), derived from a cross between soybean cultivar 'Zhongdou 27' (high isoflavone) and 'Jiunong 20' (low isoflavone), and a total of 194 simple sequence repeat (SSR) markers were used in this study. Overlapped loci of eQTLs and phenotypic QTLs (pQTLs) were analyzed to identify the potential candidate genes underlying the accumulation of isoflavone in soybean seed.
resultsThirty three eQTLs (thirteen cis-eQTLs and twenty trans-eQTLs) underlying the transcript abundance of the four gene families were identified on fifteen chromosomes. The eQTLs between Satt278-Sat_134, Sat_134-Sct_010 and Satt149-Sat_234 underlie the expression of both IFS and CHS genes. Five eQTL intervals were overlapped with pQTLs. A total of eleven candidate genes within the overlapped eQTL and pQTL were identified.
conclusionsThese results will be useful for the development of marker-assisted selection to breed soybean cultivars with high or low isoflavone contents and for map-based cloning of new isoflavone related genes.
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