ReviewWiley interdisciplinary reviews. Developmental biology
Developmental programs of lung epithelial progenitors: a balanced progenitor model.
Review in Wiley interdisciplinary reviews. Developmental biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Cell differentiation can underpin the reproducibility of morphogenesis.PLoS computational biology · 2026Article
- Hippo signaling differentially regulates distal progenitor subpopulations and their transitional states to construct the mammalian lungs.Nature communications · 2026Article
- Unraveling the FGFR-RNA splicing axis: Mechanisms, oncogenic crosstalks and innovations for therapeutic purpose.Acta pharmaceutica Sinica. B · 2026Review
- Neonatal lung-derived SSEA-1iScience · 2022Article
- Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts.Development (Cambridge, England) · 2022Article
- Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo.Nature communications · 2021Article
- A cell-centric view of lung alveologenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung.Developmental cell · 2020Article
- FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching.Science signaling · 2020Article
- Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- β-Catenin maintains lung epithelial progenitors after lung specification.Development (Cambridge, England) · 2018Article
- Article
- Leveraging Online Resources to Prioritize Candidate Genes for Functional Analyses: Using the Fetal Testis as a Test Case.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2017Review
- Creb1 regulates late stage mammalian lung development via respiratory epithelial and mesenchymal-independent mechanisms.Scientific reports · 2016Article
- The development and plasticity of alveolar type 1 cells.Development (Cambridge, England) · 2016Article
- Glucocorticoid regulation of lung development: lessons learned from conditional GR knockout mice.Molecular endocrinology (Baltimore, Md.) · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledThe daunting task of lung epithelium development is to transform a cluster of foregut progenitors into a three-dimensional (3D) tubular network with distinct cell types distributed at their appropriate locations. A complete understanding of lung development needs to address not only how, but also where, different cell types form. We propose that the lung epithelium forms through regulated deployment of three developmental programs: branching morphogenesis to expand progenitors and build a tree-like tubular network, airway differentiation to specify cells for the proximal conducting airways, and alveolar differentiation to specify cells for the peripheral gas exchange region. Each developmental program has its unique morphological features and molecular control mechanisms; their spatiotemporal coordination can be accounted for in a balanced progenitor model where progenitors balance between alternative developmental programs in response to spatiotemporal cues. This model integrates progenitor morphogenesis and differentiation, and provides new insights to lung immaturity in preterm birth and lung evolution. Advanced gene targeting and 3D imaging tools are needed to achieve a comprehensive understanding of lung epithelial progenitors on molecular, cellular, and morphological levels. For further resources related to this article, please visit the WIREs website. CONFLICT OF INTEREST: The authors have declared no conflicts of interest for this article.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.