Evidence map›Paper›PMID 25124461›Full record

SynthesisMedical science monitor : international medical journal of experimental and clinical research2014

Alteration of lipid profile in subclinical hypothyroidism: a meta-analysis.

Xiao-Li Liu, Shan He, Shao-Fang Zhang, Jun Wang, Xiu-Fa Sun, Chun-Mei Gong, Shi-Jie Zheng, Ji-Chang Zhou, Jian Xu

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiao-Li LiuMolecular Biology Lab, Shenzhen Center for Chronic Disease Control, Shenzhen, China (mainland).
Shan HeMolecular Biology lab, Shenzhen Center for Chronic Disease Control, Shenzhen, China (mainland).
Shao-Fang ZhangDepartment of Social Health, Shenzhen Luohu People's Hospital, Shenzhen, China (mainland).
Jun WangPhysicochemical Lab, Shenzhen Center for Chronic Disease Control, Shenzhen, China (mainland).
Xiu-Fa SunDepartment of Nutrition and Food Hygiene, Huazhong University of Science and Technology, Wuhan, China (mainland).
Chun-Mei GongMolecular biology lab, Shenzhen Center for Chronic Disease Control, Shenzhen, China (mainland).
Shi-Jie ZhengMolecular Biology Lab, Shenzhen Center for Chronic Disease Control, Shenzhen, China (mainland).
Ji-Chang ZhouMolecular Biology Lab, Shenzhen Center for Chronic Disease Control, Shenzhen, China (mainland).
Jian XuDepartment of Health Control, Shenzhen Center for Chronic Disease Control, Shenzhen, China (mainland).
Shenzhen Nanshan Center for Chronic Disease Control · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies yielded controversial results about the alteration of lipid profiles in patients with subclinical hypothyroidism. We performed a meta-analysis to investigate the association between subclinical hypothyroidism and lipid profiles. MATERIAL AND

methodsWe searched PubMed, Cochrane Library, and China National Knowledge Infrastructure articles published January 1990 through January 2014. Dissertation databases (PQDT and CDMD) were searched for additional unpublished articles. We included articles reporting the relationship between subclinical hypothyroidism and at least 1 parameter of lipid profiles, and calculated the overall weighted mean difference (WMD) with a random effects model. Meta-regression was used to explore the source of heterogeneity among studies, and the Egger test, Begg test, and the trim and fill method were used to assess potential publication bias.

resultsSixteen observational studies were included in our analysis. Meta-analysis suggested that the serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and total triglyceride levels were significantly increased in patients with subclinical hypothyroidism compared with euthyroidism individuals; the WMD were 12.17 mg/dl, 7.01 mg/dl, and 13.19 mg/dl, respectively (P<0.001 for all). No significant difference was observed for serum high-density lipoprotein cholesterol (HDL-C). Match strategy was the main source of heterogeneity among studies in TC and LDL-C analysis. Potential publication bias was found in TC and LDL-C analysis by the Egger test or Begg test and was not confirmed by the trim and fill method.

conclusionsSubclinical hypothyroidism may correlate with altered lipid profile. Previous studies had limitations in the control of potential confounding factors and further studies should consider those factors.

Indexed as

CholesterolCholesterol, LDLHumansHypothyroidismLipidsObservational Studies as TopicRegression AnalysisTriglyceridesCholesterolCholesterol, LDLLipidsTriglycerides

Identifiers

PMID25124461
PMCPMC4144946
OpenAlexW2168030047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.