ReviewScience (New York, N.Y.)2014
Preterm labor: one syndrome, many causes.
Review in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1,058 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Uterocervical Angle Versus Cervical Length in The Prediction Of Spontaneous Preterm Birth In Women With History Of Spontaneous Preterm Birth A Prospective Observational Study
Predictive Value of Maternal Blood Protein Signatures in Preterm Birth
Who cites it
1,058 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,949 citations in OpenAlex.
- Early-Onset Versus Late-Onset Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Maternal, Perinatal and Neonatal Outcomes.Diabetes, obesity & metabolism · 2026Pooled it
- Prognostic value of cervical length for spontaneous preterm birth in asymptomatic women with singleton pregnancy: An individual participant data meta-analysis.PLoS medicine · 2026Pooled it
- Effectiveness of oral dydrogesterone compared to placebo in reducing the risk of preterm birth: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Association between maternal multimorbidity and preterm birth: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel.BMC medicine · 2026Pooled it
- Management of threatened preterm labor based on cervical length: a randomized controlled trial.BMC pregnancy and childbirth · 2026Trial
- Associations between Nugent-bacterial vaginosis and preterm birth and other adverse pregnancy outcomes in rural northwestern Bangladesh.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Trial
- Comparative efficacy of two kangaroo care scheduling methods on depressed mood and mental health in birthing parents of preterm infants: a randomized clinical trial.BMC pregnancy and childbirth · 2026Trial
- Trial
- Docosahexaenoic acid (DHA) Supplementation During Pregnancy Reduces the Risk of Preterm Birth in Threatened Preterm Labor. The Multicenter Randomized Controlled Trial.International journal of women's health · 2025Trial
- Gut microbiome and pregnancy complications: emerging evidence and mechanistic insights.Gut microbes · 2026Review
- Integrated multi-omics profiling of amniotic fluid identifies predictive biomarkers for fetal growth restriction trajectories.Annals of medicine · 2026Article
- First-trimester non-invasive prediction of preterm birth using cell-free DNA fragmentomics.AJOG global reports · 2026Article
- Spontaneous Preterm Birth and Subsequent Cardiovascular Mortality: Linked Registry Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Single-cell-level digital twins for preterm birth prevention strategies.Science advances · 2026Article
- Early-Onset Sepsis in Preterm Neonates of 22-28 Weeks' Gestation: An International Cohort Study.Journal of pediatrics. Clinical practice · 2026Article
- Characterization of Resolved, Localized, and Progressing Infections at the Maternal-Fetal Interface in a Nonhuman Primate Model.bioRxiv : the preprint server for biology · 2026Article
- The Human Vaginal Virome: Composition, Microbiome Interactions, and Implications for Bacterial Vaginosis, HPV Persistence, and Preterm Birth.Microorganisms · 2026Review
- Intra-amniotic infection: diagnosis, nomenclature, clinical significance, management, and microbiologic tools used for the diagnosis.Clinical microbiology reviews · 2026Review
- Cervical Cerclage Performed at 24-32+0 Weeks in Twin Pregnancies: A Multicenter Descriptive Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
998 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Preterm birth is associated with 5 to 18% of pregnancies and is a leading cause of infant morbidity and mortality. Spontaneous preterm labor, a syndrome caused by multiple pathologic processes, leads to 70% of preterm births. The prevention and the treatment of preterm labor have been long-standing challenges. We summarize the current understanding of the mechanisms of disease implicated in this condition and review advances relevant to intra-amniotic infection, decidual senescence, and breakdown of maternal-fetal tolerance. The success of progestogen treatment to prevent preterm birth in a subset of patients at risk is a cause for optimism. Solving the mystery of preterm labor, which compromises the health of future generations, is a formidable scientific challenge worthy of investment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.