ArticleClinical research in cardiology : official journal of the German Cardiac Society2015
Correlation between optical coherence tomography-derived intraluminal parameters and fractional flow reserve measurements in intermediate grade coronary lesions: a comparison between diabetic and non-diabetic patients.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of imaging anatomy in predicting functional significance of coronary stenoses determined by fractional flow reserve.The international journal of cardiovascular imaging · 2017Pooled it
- Vessel fractional flow reserve (vFFR) vs. optical coherence tomography in chronic coronary syndromes (VISION-FFR).Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Article
- Consensus of the National Heart Center in collaboration With the Saudi Arabian Cardiac Interventional Society on the Clinical Use of Intracoronary Imaging.Journal of the Saudi Heart Association · 2024Article
- Morphometric Assessment for Functional Evaluation of Coronary Stenosis with Optical Coherence Tomography and the Optical Flow Ratio in a Vessel with Single Stenosis.Journal of clinical medicine · 2022Article
- The Continuum of Invasive Techniques for the Assessment of Intermediate Coronary Lesions.Diagnostics (Basel, Switzerland) · 2022Review
- Lesion Geometry as Assessed by Optical Coherence Tomography Is Related to Myocardial Ischemia as Determined by Cardiac Magnetic Resonance Imaging.Journal of clinical medicine · 2021Article
- OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses.Journal of clinical medicine · 2021Article
- Optical Coherence Tomography of the Coronary Arteries.The International journal of angiology : official publication of the International College of Angiology, Inc · 2021Review
- The assessment of intermediate coronary lesions using intracoronary imaging.Cardiovascular diagnosis and therapy · 2020Review
- Optical coherence tomography: fundamentals and clinical utility.Cardiovascular diagnosis and therapy · 2020Review
- Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics.Journal of clinical medicine · 2020Review
- Relationships of coronary culprit-plaque characteristics with duration of diabetes mellitus in acute myocardial infarction: an intravascular optical coherence tomography study.Cardiovascular diabetology · 2019Article
- Predictors for target lesion microcalcifications in patients with stable coronary artery disease: an optical coherence tomography study.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Non-culprit plaque characteristics in acute coronary syndrome patients with raised hemoglobinA1c: an intravascular optical coherence tomography study.Cardiovascular diabetology · 2018Article
- Clinical Outcomes of Deferred Lesions With Angiographically Insignificant Stenosis But Low Fractional Flow Reserve.Journal of the American Heart Association · 2017Article
- Critical analysis of the correlation between optical coherence tomography versus intravascular ultrasound and fractional flow reserve in the management of intermediate coronary artery lesion.International journal of clinical and experimental medicine · 2015Review
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5 authors.
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Abstract
backgroundFractional flow reserve (FFR) measurements accurately assess functional relevance in intermediate grade coronary lesions. A significant relationship between hemodynamic stenosis severity and optical coherence tomography (OCT)-derived intraluminal dimensions has recently been demonstrated. However, morphologic thresholds to identify significant stenoses are variable and exploration of this correlation in patients with diabetes mellitus (DM) remains currently incomplete. This study aimed at comparing the diagnostic value of intraluminal parameters as determined by OCT to predict FFR ≤0.8 in lesions of patients with versus without DM.
methodsIn 100 patients (DM = 56, non-DM = 44) with 142 coronary de novo lesions (DM = 80, non-DM = 62) of intermediate grade as determined by quantitative coronary angiography, we performed OCT and FFR. Stenoses were defined functionally relevant if FFR was ≤0.8.
resultsFFR measurements in the overall study cohort, the DM and the non-DM group correlated significantly with minimal lumen area (MLA) [overall: r (2) = 0.339, DM: r (2) = 0.341, non-DM: r (2) = 0.355 (all p < 0.001)], percent area stenosis [overall: r (2) = 0.352, DM: r (2) = 0.376, non-DM: r (2) = 0.351 (all p < 0.001)] and minimal lumen diameter [overall: r (2) = 0.333, DM: r (2) = 0.277, non-DM: r (2) = 0.417 (all p < 0.001)] without differing statistically between diabetic and non-diabetic patients (p = ns). Receiver operating characteristic analysis demonstrated that among OCT-derived parameters, MLA predicted FFR ≤0.8 with the best diagnostic efficiency and with similar cut-off values for all patients [area under the curve (AUC) = 0.836, 95% confidence interval (CI) = 0.772-0.901, cut-off value = 1.64 mm(2)] as well as for diabetic (AUC = 0.840, 95% CI = 0.754-0.927, cut-off value = 1.59 mm(2)) and non-diabetic subjects (AUC = 0.833, 95% CI = 0.734-0.932, cut-off value = 1.64 mm(2)).
conclusionIn both, diabetic and non-diabetic patients, FFR and OCT-derived intraluminal measurements are significantly correlated and OCT predicts hemodynamically relevant coronary stenosis with moderate diagnostic efficiency.
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