Evidence map›Paper›PMID 25123899›Full record

ArticleBioinformatics (Oxford, England)2014

NetComm: a network analysis tool based on communicability.

Ian M Campbell, Regis A James, Edward S Chen, Chad A Shaw

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Network bypasses sustain complexity.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ian M CampbellDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77054, USA.
Regis A JamesDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77054, USA.
Edward S ChenDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77054, USA.
Chad A ShawDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77054, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007330 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PLON, SHARON E. · 1985 to 2019
$15.6M
Initiative for Maximizing Student Development (IMSD) ProgramR25GM056929 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 1998 to 2023
$12.4M
Research Education and Career Horizons ProgramK12GM084897 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI SIFERS, RICHARD NORMAN, SLAUGHTER, GAYLE · 2008 to 2016
$8.3M
Genomic Disorders in Neurodevelopmental DiseaseF31NS083159 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI CAMPBELL, IAN MORGAN · 2013 to 2014
$67k
NIGMS NIH HHS K12 GM084897NIGMS NIH HHS R25 GM056929NIGMS NIH HHS T32 GM007330NINDS NIH HHS F31 NS083159
6 · The paper itself

Abstract

motivationSet-based network similarity metrics are increasingly used to productively analyze genome-wide data. Conventional approaches, such as mean shortest path and clique-based metrics, have been useful but are not well suited to all applications. Computational scientists in other disciplines have developed communicability as a complementary metric. Network communicability considers all paths of all lengths between two network members. Given the success of previous network analyses of protein-protein interactions, we applied the concepts of network communicability to this problem. Here we show that our communicability implementation has advantages over traditional approaches. Overall, analyses suggest network communicability has considerable utility in analysis of large-scale biological networks. AVAILABILITY AND IMPLEMENTATION: We provide our method as an R package for use in both human protein-protein interaction network analyses and analyses of arbitrary networks along with a tutorial at http://www.shawlab.org/NetComm/.

Indexed as

SoftwareDiseaseHumansProtein Interaction Mapping

Identifiers

PMID25123899
PMCPMC4274347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.