Evidence map›Paper›PMID 25123743›Full record

ReviewYearbook of medical informatics2014

Surveying Recent Themes in Translational Bioinformatics: Big Data in EHRs, Omics for Drugs, and Personal Genomics.

J C Denny

Abstract readReview
In one paragraph

Review in Yearbook of medical informatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Defining Phenotypes from Clinical Data to Drive Genomic Research.Annual review of biomedical data science · 2018
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Translational Bioinformatics: Past, Present, and Future.Genomics, proteomics & bioinformatics · 2016
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

J C DennyJoshua C. Denny, MD, MS, 2525 West End Ave - Suite 672, Nashville, TN 37213, USA, E-mail: josh.denny@vanderbilt.edu.

Funding

From GWAS to PheWAS: Scanning the EMR Phenome for Gene-disease AssociationsR01LM010685 · NLM · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BASTARACHE, LISA · 2011 to 2022
$6.3M
National Infrastructure for Standardized and Portable EHR Phenotyping AlgorithmsR01GM105688 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI LUO, YUAN, PATHAK, JYOTISHMAN · 2013 to 2020
$5.7M
Vanderbilt Genome Electronic Records ProjectU01HG006378 · NHGRI · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2011 to 2014
$4.0M
NHGRI NIH HHS U01 HG006378NIGMS NIH HHS R01 GM105688NLM NIH HHS R01 LM010685
6 · The paper itself

Abstract

objectiveTo provide a survey of recent progress in the use of large-scale biologic data to impact clinical care, and the impact the reuse of electronic health record data has made in genomic discovery.

methodSurvey of key themes in translational bioinformatics, primarily from 2012 and 2013.

resultThis survey focuses on four major themes: the growing use of Electronic Health Records (EHRs) as a source for genomic discovery, adoption of genomics and pharmacogenomics in clinical practice, the possible use of genomic technologies for drug repurposing, and the use of personal genomics to guide care.

conclusionReuse of abundant clinical data for research is speeding discovery, and implementation of genomic data into clinical medicine is impacting care with new classes of data rarely used previously in medicine.

Indexed as

Computational BiologyElectronic Health RecordsGenomicsPharmacogeneticsDiffusion of InnovationHumansTranslational Research, Biomedicalbig dataelectronic health recordsgenomicspersonalized medicineTranslational bioinformatics

Identifiers

PMID25123743
PMCPMC4287076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.