Trial reportClinical orthopaedics and related research2015
The John Charnley Award: Highly crosslinked polyethylene in total hip arthroplasty decreases long-term wear: a double-blind randomized trial.
Trial report in Clinical orthopaedics and related research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk factors for liner wear and head migration in total hip arthroplasty: a systematic review.Scientific reports · 2023Pooled it
- Long-term outcomes of total hip arthroplasty in patients younger than 55 years: a systematic review of the contemporary literatureCanadian journal of surgery. Journal canadien de chirurgie · 2019Pooled it
- Cup positioning and its effect on polyethylene wear of vitamin E- and non-vitamin E-supplemented liners in total hip arthroplasty: radiographic outcome at 5-year follow-up.Archives of orthopaedic and trauma surgery · 2023Trial
- Otto Aufranc Award: Crosslinking Reduces THA Wear, Osteolysis, and Revision Rates at 15-year Followup Compared With Noncrosslinked Polyethylene.Clinical orthopaedics and related research · 2018Trial
- Does vitamin E-blended polyethylene reduce wear in primary total hip arthroplasty: a blinded randomised clinical trial.International orthopaedics · 2017Trial
- Do oxidized zirconium femoral heads reduce polyethylene wear in cemented THAs? A blinded randomized clinical trial.Clinical orthopaedics and related research · 2015Trial
- Oxidised zirconium heads show a lower linear wear rate than 28-mm metal heads against XLPE: a retrospective analysis.Hip international : the journal of clinical and experimental research on hip pathology and therapy · 2026Article
- The Routine Use of Femoral Heads Sized 40 mm or Greater in Primary Total Hip Arthroplasty: A Review of Current Practice.Arthroplasty today · 2025Article
- Minimizing Instability in Isolated Head and Liner Exchange With the Direct Anterior Approach Using a Capsular-Sparing Technique.Arthroplasty today · 2025Article
- Impact of Prosthetic Angle Variations in Combined Anteversion Technique on Surgical Failure Rates in Developmental Dysplasia of the Hip: A 12-Year Follow-Up Study.Orthopaedic surgery · 2025Article
- The Role of Artificial Intelligence and Emerging Technologies in Advancing Total Hip Arthroplasty.Journal of personalized medicine · 2025Review
- What is the Long-term Wear of a 5-Mrad Highly Crosslinked Polyethylene Liner? A 14-year RSA Study.Clinical orthopaedics and related research · 2024Article
- [Long-term computed tomographic osteolytic analysis of highly cross-linked polyethylene prosthesis after total hip arthroplasty].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Article
- Slightly reduced early subsidence with similar outcomes and complications rate in collared stems - A systematic review of randomized clinical trials.Journal of orthopaedics · 2024Review
- Head, acetabular liner composition, and rate of revision and wear in total hip arthroplasty: a Bayesian network meta-analysis.Scientific reports · 2023Article
- Total Hip Arthroplasty: An Update on Navigation, Robotics, and Contemporary Advancements.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2023Review
- [Standard and special liner in primary hip arthroplasty : Current study and survey results from the German Arthroplasty Registry (EPRD)].Orthopadie (Heidelberg, Germany) · 2023Review
- Which femoral neck for a dual mobility cup? A biomechanical evaluation.International orthopaedics · 2022Article
- Highly cross-linked polyethylene still outperforms conventional polyethylene in THA: 10-year RSA results.Acta orthopaedica · 2021Article
- Does Activity Level After Primary Total Hip Arthroplasty Affect Aseptic Survival?Arthroplasty today · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of highly crosslinked polyethylene (HXLPE) is now commonplace for total hip arthroplasty. Hip simulator studies and short-term in vivo measurements suggest that the wear rate of some types of HXLPE is significantly less than conventional ultrahigh-molecular-weight polyethylene (UHMWPE). However, there are few long-term data to support its use. QUESTIONS/PURPOSES: The aim of this study was to measure the long-term steady-state wear of HXLPE compared with UHMWPE liners in a prospective, double-blind, randomized controlled trial using radiostereometric analysis.
methodsFifty-four patients were randomized to receive hip arthroplasties with either UHMWPE liners or HXLPE liners. Complete followup was available on 39 of these patients (72%). All patients received the same cemented stem and an uncemented acetabular component. Three-dimensional penetration of the head into the socket was determined at 10 years using a radiostereometric analysis system, which has an in vivo accuracy of <0.1 mm. Oxford Hip Scores were compared between the groups.
resultsAt 10 years there was significantly less wear of HXLPE (0.003 mm/year; 95% confidence interval [CI], ±0.010; SD 0.023; range, -0.057 to 0.074) compared with UHMWPE (0.030 mm/year; 95% CI, ±0.012; p<0.001; SD 0.0.27; range, -0.001 to 0.164). The volumetric penetration from 1 to 10 years for the UHMWPE group was 98 mm3 (95% CI, ±46 mm3; SD 102 mm3; range, -4 to 430 mm3) compared with 14 mm3 (95% CI, ±40 mm3; SD 91 mm3; range, -189 to 242 mm3) for the HXLPE group (p=0.01).
conclusionsThis study demonstrates that HXLPE has little detectable steady-state in vivo wear. This may result in fewer reoperations from loosening; however, careful clinical followup into the second decade still needs to be performed. LEVEL OF EVIDENCE: Level I, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
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