Evidence map›Paper›PMID 25123044›Full record

ArticleJournal of the American Geriatrics Society2014

Effect of Part D coverage restrictions for antidepressants, antipsychotics, and cholinesterase inhibitors on related nursing home resident outcomes.

David G Stevenson, A James O'Malley, Stacie B Dusetzina, Susan L Mitchell, Barbara J Zarowitz, Michael E Chernew, Joseph P Newhouse, Haiden A Huskamp

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pharmaceutical policies: effects of regulating drug insurance schemes.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David G StevensonDepartment of Health Policy, School of Medicine, Vanderbilt University, Nashville, Tennessee.
A James O'Malley
Stacie B Dusetzina
Susan L Mitchell
Barbara J Zarowitz
Michael E Chernew
Joseph P Newhouse
Haiden A Huskamp

Funding

North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
UNC BIRCWH CAREER DEVELOPMENT PROGRAMK12HD001441 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOGGESS, KIM A · 2000 to 2019
$9.3M
Midcareer Mentoring Award for Patient-Oriented Research in AgingK24AG033640 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI MITCHELL, SUSAN L · 2009 to 2018
$1.8M
Medicare Part D Plan Generosity & Dual-Eligible Nursing Home ResidentsR01AG034085 · NIA · HARVARD MEDICAL SCHOOL · PI HUSKAMP, HAIDEN A. · 2009 to 2011
$1.4M
Organizational Factors and the Delivery of Nursing Home CareK01AG038481 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STEVENSON, DAVID GEORGE · 2011 to 2015
$611k
NCATS NIH HHS UL1 TR001111NCATS NIH HHS UL1TR001111NIA NIH HHS K01 AG038481NIA NIH HHS K24 AG033640NIA NIH HHS K24AG033640NIA NIH HHS R01 AG034085NICHD NIH HHS 5K12HD001441-12NICHD NIH HHS K12 HD001441
6 · The paper itself

Abstract

objectivesIn 2006, Medicare Part D transitioned prescription drug coverage for dual-eligible nursing home residents from Medicaid to Medicare and randomly assigned them to Part D prescription drug plans (PDPs). Because PDPs may differ in coverage, plans may be more or less generous for drugs that an individual is taking. Taking advantage of the fact that randomization mitigates potential selection bias common in observational studies, this study sought to assess the effect of PDP coverage on resident outcomes for three medication classes--antidepressants, antipsychotics, and cholinesterase inhibitors.

designRetrospective cohort study to examine the effect of coverage restrictions--including noncoverage and coverage with restrictions--on depression, hallucinations and delusions, aggressive behaviors, cognitive performance, and activities of daily living for dual-eligible nursing home residents randomized to PDPs in 2006 to 2008. The analyses further adjusted for baseline health status to address any residual imbalances in the comparison groups.

settingLinked data from Medicare claims, Minimum Data Set assessments, pharmacy claims, and PDP formulary information.

participantsDual-eligible nursing home residents aged 65 and older living in facilities that contracted with a single pharmacy provider.

resultsPDP coverage restrictions in three medication classes of interest were not significantly associated with the resident outcomes examined. Although cholinesterase inhibitor users facing coverage restrictions had a 0.04-point lower depression rating score than residents facing no restrictions, this difference was not statistically significant after adjusting for multiple comparisons.

conclusionThe findings suggest that exogenous changes in coverage for three commonly used medication classes had no detectable effect on nursing home resident outcomes in 2006 to 2008. There are several possible explanations for this lack of association, including the role of policy protections for dual-eligible nursing home residents and the possibility that suitable clinical alternatives were identified or that previously used medications offered little clinical benefit.

Indexed as

Medicare Part DNursing HomesAgedAged, 80 and overAggressionAntidepressive AgentsAntipsychotic AgentsCholinesterase InhibitorsCognition DisordersCohort StudiesDelusionsDepressionDisability EvaluationDual Medicare Medicaid EligibilityFemaleHallucinationsAntidepressive AgentsAntipsychotic AgentsCholinesterase Inhibitorscoverage restrictionsMedicare Part Dnursing home

Identifiers

PMID25123044
PMCPMC4172511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.