ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Volitional walking via upper limb muscle-controlled stimulation of the lumbar locomotor center in man.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Cybernic treatment with wearable cyborg Hybrid Assistive Limb (HAL) improves ambulatory function in patients with slowly progressive rare neuromuscular diseases: a multicentre, randomised, controlled crossover trial for efficacy and safety (NCY-3001).Orphanet journal of rare diseases · 2021Trial
- Non-invasive closed-loop spinal stimulation restores leg stepping control in humans with paraplegia.Brain : a journal of neurology · 2026Article
- Specific recruitment properties of spinal reflex of thigh muscle in sprinter.Scientific reports · 2025Article
- Effects of body weight-supported overground training on gait recovery in severe stroke-induced hemiplegia: a single-case ABAB design.Journal of physical therapy science · 2025Article
- Article
- Activation of human spinal locomotor circuitry using transvertebral magnetic stimulation.Frontiers in human neuroscience · 2022Article
- Non-invasive brain-spine interface: Continuous control of trans-spinal magnetic stimulation using EEG.Frontiers in bioengineering and biotechnology · 2022Article
- Modulation of H-reflex responses and frequency-dependent depression by repetitive spinal electromagnetic stimulation: From rats to humans and back to chronic spinal cord injured rats.The European journal of neuroscience · 2020Article
- Forelimb force direction and magnitude independently controlled by spinal modules in the macaque.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Future of Tanscranial Magnetic Stimulation in Movement Disorders: Introduction of Novel Methods.Journal of movement disorders · 2020Article
- Bypassing stroke-damaged neural pathways via a neural interface induces targeted cortical adaptation.Nature communications · 2019Article
- Strategies to augment volitional and reflex function may improve locomotor capacity following incomplete spinal cord injury.Journal of neurophysiology · 2018Review
- Regenerative Rehabilitation: Combining Stem Cell Therapies and Activity-Dependent Stimulation.Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association · 2017Article
- Implantable neurotechnologies: bidirectional neural interfaces--applications and VLSI circuit implementations.Medical & biological engineering & computing · 2016Review
- Erratum to: Implantable neurotechnologies: bidirectional neural interfaces--applications and VLSI circuit implementations.Medical & biological engineering & computing · 2016Article
- Spinal primitives and intra-spinal micro-stimulation (ISMS) based prostheses: a neurobiological perspective on the "known unknowns" in ISMS and future prospects.Frontiers in neuroscience · 2015Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gait disturbance in individuals with spinal cord lesion is attributed to the interruption of descending pathways to the spinal locomotor center, whereas neural circuits below and above the lesion maintain their functional capability. An artificial neural connection (ANC), which bridges supraspinal centers and locomotor networks in the lumbar spinal cord beyond the lesion site, may restore the functional impairment. To achieve an ANC that sends descending voluntary commands to the lumbar locomotor center and bypasses the thoracic spinal cord, upper limb muscle activity was converted to magnetic stimuli delivered noninvasively over the lumbar vertebra. Healthy participants were able to initiate and terminate walking-like behavior and to control the step cycle through an ANC controlled by volitional upper limb muscle activity. The walking-like behavior stopped just after the ANC was disconnected from the participants even when the participant continued to swing arms. Furthermore, additional simultaneous peripheral electrical stimulation to the foot via the ANC enhanced this walking-like behavior. Kinematics of the induced behaviors were identical to those observed in voluntary walking. These results demonstrate that the ANC induces volitionally controlled, walking-like behavior of the legs. This paradigm may be able to compensate for the dysfunction of descending pathways by sending commands to the preserved locomotor center at the lumbar spinal cord and may enable individuals with paraplegia to regain volitionally controlled walking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.