ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Recycling endosomes undergo rapid closure of a fusion pore on exocytosis in neuronal dendrites.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 50 citations in OpenAlex.
- Membrane lipid poly-unsaturation selectively affects dopamine D2 receptor endocytosis.Nature communications · 2026Article
- Article
- Imaging of post-synaptic membrane trafficking in neuronal dendrites: progress, limitations, and new developments.Neurophotonics · 2023Article
- Article
- The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes.Cellular and molecular life sciences : CMLS · 2022Article
- Gain-of-Function Dynamin-2 Mutations Linked to Centronuclear Myopathy Impair CaInternational journal of molecular sciences · 2022Article
- Article
- Spatial regulation of endosomes in growing dendrites.Developmental biology · 2022Review
- The role of pectin phase separation in plant cell wall assembly and growth.Cell surface (Amsterdam, Netherlands) · 2021Review
- NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95.Nature communications · 2021Article
- Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons.Frontiers in molecular neuroscience · 2021Article
- Imaging endocytic vesicle formation at high spatial and temporal resolutions with the pulsed-pH protocol.Nature protocols · 2020Article
- Article
- Article
- News about non-secretory exocytosis: mechanisms, properties, and functions.Journal of molecular cell biology · 2019Review
- Suppression of AMPA Receptor Exocytosis Contributes to Hippocampal LTD.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Visualization of Exo- and Endocytosis of AMPA Receptors During Hippocampal Synaptic Plasticity Around Postsynaptic-Like Membrane Formed on Glass Surface.Frontiers in cellular neuroscience · 2018Article
- Recent Findings on AMPA Receptor Recycling.Frontiers in cellular neuroscience · 2018Review
- RCAN1 Knockdown Reverts Defects in the Number of Calcium-Induced Exocytotic Events in a Cellular Model of Down Syndrome.Frontiers in cellular neuroscience · 2018Article
- Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms.Cell reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exocytosis of recycling endosomes (REs) represents the last step of receptor and membrane recycling, a fundamental process involved in many aspects of cell physiology. In neurons, it is involved in the control of cell polarity and synaptic plasticity and is locally and tightly regulated. However, its molecular mechanisms are still poorly understood. We have imaged single exocytosis events of REs in rat hippocampal neurons in culture transfected with three types of receptors tagged with the pH-sensitive GFP mutant superecliptic phluorin. We found that exocytosis events are grouped into two categories: (1) short burst events in which receptors diffuse into the plasma membrane in a few seconds; and (2) long display events in which receptors remain visible and clustered after exocytosis for many seconds. Display events are much rarer in non-neuronal cells, such as fibroblasts and astrocytes. Using two-color imaging and fast extracellular solution changes, we show that display events correspond to the rapid opening and closing of a fusion pore (or "kiss-and-run") with a median opening time of 2.6 s, which restricts the diffusion of multiple receptor types and bound cargo. Moreover, the RE marker Rab11 remains enriched after display exocytosis events and controls the mode of RE exocytosis. Finally, a given RE can undergo multiple rounds of display exocytosis. The last step of recycling can thus be controlled in neurons for the selective delivery of receptors at the cell surface.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.