ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Differential contribution of hippocampal subfields to components of associative taste learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Improving taste sensitivity in healthy adults using taste recall training: a randomized controlled trial.Scientific reports · 2022Trial
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- Loss of control eating in children is associated with altered cortical and subcortical brain structure.Frontiers in psychology · 2023Article
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- Memory and eating: A bidirectional relationship implicated in obesity.Neuroscience and biobehavioral reviews · 2022Review
- Interaction of Taste and Place Coding in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms.Biological psychiatry · 2017Review
- Complementary subicular pathways to the anterior thalamic nuclei and mammillary bodies in the rat and macaque monkey brain.The European journal of neuroscience · 2016Article
- Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A molecular mechanism underlying gustatory memory trace for an association in the insular cortex.eLife · 2015Article
- Dissociation of the Role of Infralimbic Cortex in Learning and Consolidation of Extinction of Recent and Remote Aversion Memory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis.Neural plasticity · 2015Review
- The roles of protein expression in synaptic plasticity and memory consolidation.Frontiers in molecular neuroscience · 2014Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to associate the consumption of a taste with its positive or negative consequences is fundamental to survival and influences the behavior of species ranging from invertebrate to human. As a result, for both research and clinical reasons, there has been a great effort to understand the neuronal circuits, as well as the cellular and molecular mechanisms, underlying taste learning. From a neuroanatomical perspective, the contributions of the cortex and amygdala are well documented; however, the literature is riddled with conflicting results regarding the role of the hippocampus in different facets of taste learning. Here, we use conditional genetics in mice to block NMDA receptor-dependent plasticity individually in each of the three major hippocampal subfields, CA1, CA3, and the dentate gyrus, via deletion of the NR1 subunit. Across the CA1, CA3, and dentate gyrus NR1 knock-out lines, we uncover a pattern of differential deficits that establish the dispensability of hippocampal plasticity in incidental taste learning, the requirement of CA1 plasticity for associative taste learning, and a specific requirement for plasticity in the dentate gyrus when there is a long temporal gap between the taste and its outcome. Together, these data establish that the hippocampus is involved in associative taste learning and suggest an episodic component to this type of memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.