ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
NMDA spike/plateau potentials in dendrites of thalamocortical neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Behavioral timescale synaptic plasticity: properties, elements and functions.Nature neuroscience · 2026Review
- Dynamic corticothalamic modulation of the somatosensory thalamocortical circuit during wakefulness.Nature communications · 2024Article
- Article
- Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN.eLife · 2022Article
- Crossed Connections From Insular Cortex to the Contralateral Thalamus.Frontiers in neural circuits · 2021Article
- Local glutamate-mediated dendritic plateau potentials change the state of the cortical pyramidal neuron.Journal of neurophysiology · 2021Article
- L-type calcium channels refine the neural population code of sound level.Journal of neurophysiology · 2016Article
- Biophysical Network Modelling of the dLGN Circuit: Different Effects of Triadic and Axonal Inhibition on Visual Responses of Relay Cells.PLoS computational biology · 2016Article
- Passive Synaptic Normalization and Input Synchrony-Dependent Amplification of Cortical Feedback in Thalamocortical Neuron Dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Functions of synapsins in corticothalamic facilitation: important roles of synapsin I.The Journal of physiology · 2015Article
- Distinctive receptive field and physiological properties of a wide-field amacrine cell in the macaque monkey retina.Journal of neurophysiology · 2015Article
- CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy.Genes & development · 2015Article
- Article
- Spiny neurons of amygdala, striatum, and cortex use dendritic plateau potentials to detect network UP states.Frontiers in cellular neuroscience · 2014Article
- A synaptic mechanism for network synchrony.Frontiers in cellular neuroscience · 2014Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic NMDA spike/plateau potentials, first discovered in cortical pyramidal neurons, provide supralinear integration of synaptic inputs on thin and distal dendrites, thereby increasing the impact of these inputs on the soma. The more specific functional role of these potentials has been difficult to clarify, partly due to the complex circuitry of cortical neurons. Thalamocortical (TC) neurons in the dorsal lateral geniculate nucleus participate in simpler circuits. They receive their primary afferent input from retina and send their output to visual cortex. Cortex, in turn, regulates this output through massive feedback to distal dendrites of the TC neurons. The TC neurons can operate in two modes related to behavioral states: burst mode prevailing during sleep, when T-type calcium bursts largely disrupt the transfer of signals from retina to cortex, and tonic mode, which provides reliable transfer of retinal signals to cortex during wakefulness. We studied dendritic potentials in TC neurons with combined two-photon calcium imaging and whole-cell recording of responses to local dendritic glutamate iontophoresis in acute brain slices from mice. We found that NMDA spike/plateaus can be elicited locally at distal dendrites of TC neurons. We suggest that these dendritic potentials have important functions in the cortical regulation of thalamocortical transmission. NMDA spike/plateaus can induce shifts in the functional mode from burst to tonic by blockade of T-type calcium conductances. Moreover, in tonic mode, they can facilitate the transfer of retinal signals to cortex by depolarization of TC neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.