ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
High-NaCl perception in Drosophila melanogaster.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Insulin and leucokinin pathways coordinate adaptive salt appetite inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Activity and State-Dependent Modulation of Salt Taste Behavior Via Pharyngeal Neurons inNeuroscience insights · 2026Article
- The Drosophila DEG/ENaC PPK12 is a NaScientific reports · 2025Article
- Article
- Opponent coding mechanisms in Drosophila taste neurons.Chemical senses · 2025Review
- Food hardness preference reveals multisensory contributions of fly larval gustatory organs in behaviour and physiology.PLoS biology · 2025Article
- Molecular and cellular basis of sodium sensing iniScience · 2024Article
- Article
- An inhibitory mechanism for suppressing high salt intake in Drosophila.Chemical senses · 2023Article
- The chemosensory system of theFly · 2022Review
- Article
- Review
- The taste of water.eLife · 2019Article
- The taste of ribonucleosides: Novel macronutrients essential for larval growth are sensed by Drosophila gustatory receptor proteins.PLoS biology · 2018Article
- Salt an Essential Nutrient: Advances in Understanding Salt Taste Detection UsingJournal of experimental neuroscience · 2018Review
- Nitric oxide contributes to high-salt perception in a blood-sucking insect model.Scientific reports · 2017Article
- Antimicrobial Activities and Time-Kill Kinetics of Extracts of Selected Ghanaian Mushrooms.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain.Nature communications · 2016Article
- Gustatory processing and taste memory in Drosophila.Journal of neurogenetics · 2016Review
- Caffeine Taste Signaling in Drosophila Larvae.Frontiers in cellular neuroscience · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salt is a fundamental nutrient that is required for many physiological processes, including electrolyte homeostasis and neuronal activity. In mammals and Drosophila, the detection of NaCl induces two different behaviors: low-salt concentrations provide an attractive stimulus, whereas high-salt concentrations are avoided. We identified the gene called serrano (sano) as being expressed in the sensory organs of Drosophila larvae. A transgenic reporter line showed that sano was coexpressed with Gr66a in a subset of gustatory neurons in the terminal organ of third-instar larvae. The disruption of sano gene expression in gustatory neurons led to the specific loss of high-salt concentration avoidance in larvae, whereas the detection of other attractive or aversive substances was unaffected. Moreover, using a cellular marker sensitive to calcium levels, Sano function was shown to be required for neuronal activity in response to high-salt concentrations. In these neurons, the loss of the DEG/ENaC channel PPK19 function also eliminated the cellular response to high-salt concentrations. Our study revealed that PPK19 and Sano are required in the neurons of the larval gustatory organs for the detection of high-salt concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.