Evidence map›Paper›PMID 25122865›Full record

ArticleJournal of clinical microbiology2014

Mutational analysis of Pneumocystis jirovecii dihydropteroate synthase and dihydrofolate reductase genes in HIV-infected patients in China.

Xilong Deng, Li Zhuo, Yun Lan, Zhaoxia Dai, Wan-shan Chen, Weiping Cai, Joseph A Kovacs, Liang Ma, Xiaoping Tang

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Molecular Study ofJournal of fungi (Basel, Switzerland) · 2024
    Article
  2. Trends in the Epidemiology ofJournal of fungi (Basel, Switzerland) · 2023
    Review
  3. Genetic Polymorphisms ofPolish journal of microbiology · 2022
    Article
  4. Article
  5. Review
  6. Epidemiology of fungal infections in China.Frontiers of medicine · 2018
    Review
  7. [Research progress on genes mutations related to sulfa drug resistance inZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2017
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Xilong DengIntensive Care Unit, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China Critical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA.
Li ZhuoDepartment of Infectious Diseases, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China.
Yun LanDepartment of Laboratory Medicine, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China.
Zhaoxia DaiDepartment of Infectious Diseases, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China.
Wan-shan ChenDepartment of Laboratory Medicine, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China.
Weiping CaiDepartment of Infectious Diseases, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China.
Joseph A KovacsCritical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA.
Liang MaCritical Care Medicine Department, NIH Clinical Center, Bethesda, Maryland, USA.
Xiaoping TangDepartment of Infectious Diseases, Guangzhou No. 8 People's Hospital, Guangzhou, Guangdong Province, China xtang@21cn.com.
National Institutes of Health Clinical Center · USTwelfth Guangzhou City People's Hospital · CN

Funding

Molecular Studies Of Human Pneumocystis CariniiZIACL000192 · CLC · CLINICAL CENTER · PI KOVACS, JOSEPH A · 2009 to 2025
$0k
Intramural NIH HHS
6 · The paper itself

Abstract

We investigated Pneumocystis jirovecii dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) genes for mutations in 25 Chinese HIV-infected patients with P. jirovecii pneumonia. We identified DHPS mutations in 3 (12%) patients and DHFR mutations in 1 (4%) patient. The prevalence of DHPS and DHFR mutations in China remains low, as it does in other developing countries.

Indexed as

MutationAdultChinaDihydropteroate SynthaseFemaleHIV InfectionsHumansMaleMiddle AgedMutant ProteinsPneumocystis cariniiPrevalenceTetrahydrofolate DehydrogenaseDihydropteroate SynthaseMutant ProteinsTetrahydrofolate Dehydrogenase

Identifiers

PMID25122865
PMCPMC4313241
OpenAlexW2017856160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.