SynthesisCanadian family physician Medecin de famille canadien2014
Systematic review of clinical features of suspected colorectal cancer in primary care.
Synthesis in Canadian family physician Medecin de famille canadien, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Guideline for referral of patients with suspected colorectal cancer by family physicians and other primary care providers.Canadian family physician Medecin de famille canadien · 2014Pooled it
- Safety and efficacy of transcatheter arterial infusion chemotherapy combined with Lipiodol chemoembolization for advanced colorectal cancer with bleeding: a retrospective single-center clinical study of 119 patients in China.Quantitative imaging in medicine and surgery · 2026Article
- The Value of Colonoscopy in Assessing Rectal Bleeding in Patients Referred From Outpatient Care Units in Erbil, Iraq.Cureus · 2024Article
- Early Symptom Patterns by Tumor Laterality, Age at Onset, Stage, and Symptom-to-Treatment Initiation in Patients with Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Development and Implementation of a Digital Quality Measure of Emergency Cancer Diagnosis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Article
- Topical treatments for anal fissure.Canadian family physician Medecin de famille canadien · 2023Article
- How can we better identify patients with rectal bleeding who are at high risk of colorectal cancer? An observational study.International journal of colorectal disease · 2022Observational
- The EPAGE guidelines are not an effective strategy for managing colonoscopies during the COVID-19 pandemic.Gastroenterologia y hepatologia · 2022Article
- Cancer diagnosis in primary care: Six steps to reducing the diagnostic interval.Canadian family physician Medecin de famille canadien · 2021Article
- Article
- Discovery of core gene families associated with liver metastasis in colorectal cancer and regulatory roles in tumor cell immune infiltration.Translational oncology · 2021Article
- The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal.Cancers · 2020Review
- Components of the full blood count as risk factors for colorectal cancer detection: a systematic review protocol.BMJ open · 2019Article
- Factors Associated with Prolonged Patient-Attributable Delay in the Diagnosis of Colorectal Cancer.Cancer research and treatment · 2018Observational
- Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia.Medicine · 2016Observational
- Anemia and iron deficiency in gastrointestinal and liver conditions.World journal of gastroenterology · 2016Review
- Colorectal Carcinomas in Uyo City, Southern Geopolitical Zone of Nigeria: A Review of Clinicopathological Characteristics and Literature.Rare tumors · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo systematically review the diagnostic accuracy of clinical features associated with colorectal cancer (CRC) presenting in primary care. DATA SOURCES: MEDLINE and EMBASE were searched for studies in primary care that provided information on clinical features predictive of CRC. Positive predictive values were used to guide the determination of clinical features associated with increased risk of CRC. STUDY SELECTION: Systematic reviews or primary studies that provided possible clinical features predictive of CRC were included. SYNTHESIS: Clinical features of patients presenting in primary care that are associated with increased risk of CRC, listed in descending order of association, included palpable rectal or abdominal mass; rectal bleeding combined with weight loss; iron deficiency anemia; rectal bleeding mixed with stool; rectal bleeding in the absence of perianal symptoms; rectal bleeding combined with change in bowel habits; dark rectal bleeding; rectal bleeding and diarrhea; and change in bowel habits. Being male and increasing age were also, in general, associated with increased risk of CRC.
conclusionRecognition of clinical features associated with increased risk of CRC by FPs might help with earlier identification and referral among patients presenting in primary care. This review might help inform providers and CRC diagnostic assessment programs about indications for assessment and further investigation.
Indexed as
Identifiers
25122831PMC4131977W2163848079What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.