Evidence map›Paper›PMID 25122775›Full record

ArticleJournal of virology2014

HIV vaccine trial exploits a dual and central role for innate immunity.

Deborah Heydenburg Fuller, Laura E Richert-Spuhler, Nichole R Klatt

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Deborah Heydenburg FullerDepartment of Microbiology, University of Washington, Seattle, Washington, USA Washington National Primate Research Center, Seattle, Washington, USA fullerdh@u.washington.edu klattnr@u.washington.edu.
Laura E Richert-SpuhlerWashington National Primate Research Center, Seattle, Washington, USA Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Nichole R KlattWashington National Primate Research Center, Seattle, Washington, USA Department of Pharmaceutics, University of Washington, Seattle, Washington, USA fullerdh@u.washington.edu klattnr@u.washington.edu.
University of Washington · US

Funding

Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
NIAID NIH HHS T32 AI007140NIH HHS P51 OD010425
6 · The paper itself

Abstract

Limited understanding of correlates of protection from HIV transmission hinders development of an efficacious vaccine. D. J. M. Lewis and colleagues (J. Virol. 88:11648-11657, 2014, doi:10.1128/JVI.01621-14) now report that vaginal immunization with an HIVgp140 vaccine linked to the 70-kDa heat shock protein downregulated the human immunodeficiency virus (HIV) coreceptor CCR5 (chemokine [C-C motif] receptor 5) and increased expression of the HIV resistance factor APOBEC3G (apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G), in women. These effects correlated with HIV suppression ex vivo. Thus, vaccine-induced innate responses not only facilitate adaptive immunity-they may prove to be critical for preventing HIV transmission.

Indexed as

Immunity, InnateVaginaAIDS VaccinesAnimalsFemaleHIV-1HIV Envelope Protein gp41HSP70 Heat-Shock ProteinsHumansT-LymphocytesVirus ReplicationAIDS VaccinesHIV Envelope Protein gp41HSP70 Heat-Shock Proteins

Identifiers

PMID25122775
PMCPMC4178753
OpenAlexW1989749493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.