ArticleJournal of neurophysiology2014
Role of spinal bombesin-responsive neurons in nonhistaminergic itch.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Kappa opioids inhibit spinal output neurons to suppress itch.Science advances · 2024Article
- Identification of a convergent spinal neuron population that encodes itch.bioRxiv : the preprint server for biology · 2023Article
- Bombesins: A New Frontier in Hybrid Compound Development.Pharmaceutics · 2023Review
- Generalized resistance to pruritogen-induced scratching in the C3H/HeJ strain.Frontiers in molecular neuroscience · 2022Article
- Low-Threshold Mechanosensitive VGLUT3-Lineage Sensory Neurons Mediate Spinal Inhibition of Itch by Touch.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Challenge of Basic Itch Research.Acta dermato-venereologica · 2020Review
- Calcium imaging of primary canine sensory neurons: Small-diameter neurons responsive to pruritogens and algogens.Brain and behavior · 2019Article
- Effects of pruritogens and algogens on rostral ventromedial medullary ON and OFF cells.Journal of neurophysiology · 2018Article
- Opposing effects of cervical spinal cold block on spinal itch and pain transmission.Itch (Philadelphia, Pa.) · 2018Article
- Innocuous warming enhances peripheral serotonergic itch signaling and evokes enhanced responses in serotonin-responsive dorsal horn neurons in the mouse.Journal of neurophysiology · 2017Article
- Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?Clinical reviews in allergy & immunology · 2016Review
- Anatomical evidence of pruriceptive trigeminothalamic and trigeminoparabrachial projection neurons in mice.The Journal of comparative neurology · 2016Article
- Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus.Neuropharmacology · 2015Article
- Intradermal endothelin-1 excites bombesin-responsive superficial dorsal horn neurons in the mouse.Journal of neurophysiology · 2015Article
- A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch.Pain · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Intrathecal administration of the neurotoxin bombesin-saporin reduces or abolishes pruritogen-evoked scratching behavior. We investigated whether spinal neurons that respond to intradermal (ID) injection of pruritogens also respond to spinal superfusion of bombesin and vice versa. Single-unit recordings were made from superficial lumbar spinal dorsal horn neurons in anesthetized mice. We identified neurons with three search strategies: 1) ID injection of the nonhistaminergic itch mediator chloroquine, 2) spinal superfusion of bombesin, and 3) noxious pinch. All units were tested with an array of itch mediators (chloroquine, histamine, SLIGRL, BAM8-22), algogens [capsaicin, allyl isothiocyanate (AITC)], and physical stimuli (brush, pinch, noxious heat, cooling) applied to the hindlimb receptive field. The vast majority of chloroquine-responsive units also responded to bombesin. Of 26 chloroquine-sensitive units tested, most responded to SLIGRL, half responded to histamine and/or BAM8-22, and most responded to capsaicin and/or AITC as well as noxious thermal and mechanical stimuli. Of 29 bombesin-responsive units, a large majority also responded to other itch mediators as well as AITC, capsaicin, and noxious thermal and mechanical stimuli. Responses to successive applications of bombesin exhibited tachyphylaxis. In contrast, of 36 units responsive to noxious pinch, the majority (67%) did not respond to ID chloroquine or spinal bombesin. It is suggested that chloroquine- and bombesin-sensitive spinal neurons signal itch from the skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.