Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Bed rest promotes reductions in walking speed, functional parameters, and aerobic fitness in older, healthy adults.
Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 3 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- The role of muscle disuse in muscular and cardiovascular fitness: A systematic review and meta-regression.European journal of sport science · 2024Pooled it
- Behaviour change interventions to increase physical activity in hospitalised patients: a systematic review, meta-analysis and meta-regression.Age and ageing · 2022Pooled it
- Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Pooled it
- Trial
- Essential amino acid enriched meal replacement improves body composition and physical function in obese older adults: A randomized controlled trial.Clinical nutrition ESPEN · 2022Trial
- Effectiveness of early cardiac rehabilitation in patients with heart valve surgery: a randomized, controlled trial.The Journal of international medical research · 2022Trial
- Trial
- Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial: Design and rationale.American heart journal · 2017Trial
- Effects of short-term dry immersion on bone remodeling markers, insulin and adipokines.PloS one · 2017Trial
- Leucine partially protects muscle mass and function during bed rest in middle-aged adults.The American journal of clinical nutrition · 2016Trial
- Musculoskeletal decay and bone-muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures.Experimental physiology · 2026Review
- Associations of length of stay with sarcopenia parameters in geriatric patients: age and sex differences in the oldest old.Aging clinical and experimental research · 2026Article
- Gait analysis for functional evaluation in a surgical hindlimb suspension model of muscle atrophy.The Journal of physiology · 2026Article
- Impact of 14 days of head-down bed rest and an exercise countermeasure on skeletal muscle atrophy, proteome and circulatory cytokines in older adults.Experimental physiology · 2026Article
- Reduced walking speed at discharge predicts mortality after clinical osteoporotic vertebral fracture: A retrospective cohort study.Archives of osteoporosis · 2026Article
- Differences in Pain Management Strategies Between Mobile and Immobile Hospitalized Patients: A Real-World Data Analysis.Pain research & management · 2026Article
- Effects of neuromuscular electrical stimulation on voluntary muscle activation and peripheral muscle contractility following short-term bed rest.Experimental physiology · 2025Article
- Associations between body composition and hospitalization in patients undergoing maintenance hemodialysis.Geriatrics & gerontology international · 2025Article
- Non-contact, non-visual, multi-person hallway gait monitoring.Scientific reports · 2025Article
- Association between bed-rest time, food intake, and constipation in older nursing home residents.Geriatrics & gerontology international · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
contextThe exact relationship between the bed rest-induced loss of skeletal muscle and reductions in muscle strength and physical performance in the older individuals is still unclear.
objectiveWe examined the effect of 10 days of bed rest on changes in regional body composition, muscle strength, and functional status, and the relationship between these variables in older individuals. DESIGN, PARTICIPANTS, AND
interventionRegional body composition was measured using dual energy x-ray absorptiometry. We also determined changes in leg strength and several indices of functional status, including walking speed.
resultsBody weight, body mass index, and total and lower extremity lean mass decreased with bed rest. There were also significant reductions in knee extension one repetition maximum, isometric knee extension, knee extension 60° concentric, stair ascent time, stair ascent power, stair descent time, VO2 max, floor transfer test, 5-minute walk time, and chair stand. The overall change in total and lower extremity lean mass was also directly related to bed rest-induced reductions in one repetition maximum knee extension.
conclusionsBed rest promoted overall declines in muscle mass, muscle strength, and physical function in older individuals. The changes in lean tissue were closely correlated with the bed rest-induced decline of muscle strength.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.