ArticleIEEE transactions on medical imaging2015
Comb-push ultrasound shear elastography (CUSE) for evaluation of thyroid nodules: preliminary in vivo results.
Article in IEEE transactions on medical imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Local phase velocity imaging with wavenumber filter banks for ultrasound shear wave elastography.Computer methods and programs in biomedicine · 2025Article
- The diagnostic value of convolutional neural networks in thyroid cancer detection using ultrasound images.Frontiers in oncology · 2025Article
- Ultrasound Shear Elastography With Expanded Bandwidth (USEWEB): A Novel Method for 2D Shear Phase Velocity Imaging of Soft Tissues.IEEE transactions on medical imaging · 2024Article
- Shear Induced Non-Linear Elasticity Imaging: Elastography for Compound Deformations.IEEE transactions on medical imaging · 2020Article
- Local Phase Velocity Based Imaging: A New Technique Used for Ultrasound Shear Wave Elastography.IEEE transactions on medical imaging · 2019Article
- An investigation into the sensitivity of shear wave ultrasound elastography to measure the anterior bladder wall pressure in patients with neurogenic bladder.Journal of family medicine and primary care · 2019Article
- Ultrasound elastography of the thyroid: principles and current status.Ultrasonography (Seoul, Korea) · 2019Article
- Evaluation of Reconstruction Parameters for 2-D Comb-Push Ultrasound Shear Wave Elastography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019Article
- A soft cervix, categorized by shear-wave elastography, in women with short or with normal cervical length at 18-24 weeks is associated with a higher prevalence of spontaneous preterm delivery.Journal of perinatal medicine · 2018Article
- Comparative study on the diagnostic values of different ultrasound technologies for malignant thyroid nodules.Oncology letters · 2018Article
- Article
- Mechanics of ultrasound elastography.Proceedings. Mathematical, physical, and engineering sciences · 2017Review
- Diagnostic features of quantitative comb-push shear elastography for breast lesion differentiation.PloS one · 2017Article
- Fully Automated and Robust Tracking of Transient Waves in Structured Anatomies Using Dynamic Programming.Ultrasound in medicine & biology · 2016Article
- Article
- Article
- Update on Breast Cancer Detection Using Comb-Push Ultrasound Shear Elastography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2015Article
- Effect of Calcifications on Breast Ultrasound Shear Wave Elastography: An Investigational Study.PloS one · 2015Article
- Comb-push ultrasound shear elastography of breast masses: initial results show promise.PloS one · 2015Article
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8 authors.
Funding
Abstract
In clinical practice, an overwhelming majority of biopsied thyroid nodules are benign. Therefore, there is a need for a complementary and noninvasive imaging tool to provide clinically relevant diagnostic information about thyroid nodules to reduce the rate of unnecessary biopsies. The goal of this study was to evaluate the feasibility of utilizing comb-push ultrasound shear elastography (CUSE) to measure the mechanical properties (i.e., stiffness) of thyroid nodules and use this information to help classify nodules as benign or malignant. CUSE is a fast and robust 2-D shear elastography technique in which multiple laterally distributed acoustic radiation force beams are utilized simultaneously to produce shear waves. Unlike other shear elasticity imaging modalities, CUSE does not suffer from limited field of view (FOV) due to shear wave attenuation and can provide a large FOV at high frame rates. To evaluate the utility of CUSE in thyroid imaging, a preliminary study was performed on a group of five healthy volunteers and 10 patients with ultrasound-detected thyroid nodules prior to fine needle aspiration biopsy. The measured shear wave speeds in normal thyroid tissue and thyroid nodules were converted to Young's modulus (E), indicating a measure of tissue stiffness. Our results indicate an increase in E for thyroid nodules compared to normal thyroid tissue. This increase was significantly higher in malignant nodules compared to benign. The Young's modulus in normal thyroid tissue, benign and malignant nodules were found to be 23.2 ±8.29 kPa, 91.2±34.8 kPa, and 173.0±17.1 kPa, respectively. Results of this study suggest the utility of CUSE in differentiating between benign and malignant thyroid nodules.
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