ReviewBiology of reproduction2014
Genetic alterations affecting cholesterol metabolism and human fertility.
Review in Biology of reproduction, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Genetics and reproduction in buffalo: latest insights into the genetic architecture of reproductive traits.The Journal of reproduction and development · 2026Review
- Regulation of testosterone synthesis by circadian clock genes and its research progress in male diseases.Asian journal of andrology · 2025Review
- Facial Appearance and Markers of Cardiometabolic Risk in Healthy Adult Men.Archives of sexual behavior · 2025Article
- Age-related testosterone decline: mechanisms and intervention strategies.Reproductive biology and endocrinology : RB&E · 2024Review
- The relationship between cardiometabolic index and infertility in American adults: a population-based study.Frontiers in endocrinology · 2024Article
- Maternal hypercholesterolemia would increase the incidence of embryo aneuploidy in couples with recurrent implantation failure.European journal of medical research · 2023Article
- Review
- Transcriptome Analysis of Thiram-Treated Zebrafish (Biology · 2023Article
- Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility.International journal of molecular sciences · 2020Review
- Women's prepregnancy lipid levels and number of children: a Norwegian prospective population-based cohort study.BMJ open · 2018Article
- Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells.The Journal of cell biology · 2018Article
- Personalized medicine: motivation, challenges, and progress.Fertility and sterility · 2018Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Single nucleotide polymorphisms (SNPs) represent genetic variations among individuals in a population. In medicine, these small variations in the DNA sequence may significantly impact an individual's response to certain drugs or influence the risk of developing certain diseases. In the field of reproductive medicine, a significant amount of research has been devoted to identifying polymorphisms which may impact steroidogenesis and fertility. This review discusses current understanding of the effects of genetic variations in cholesterol metabolic pathways on human fertility that bridge novel linkages between cholesterol metabolism and reproductive health. For example, the role of the low-density lipoprotein receptor (LDLR) in cellular metabolism and human reproduction has been well studied, whereas there is now an emerging body of research on the role of the high-density lipoprotein (HDL) receptor scavenger receptor class B type I (SR-BI) in human lipid metabolism and female reproduction. Identifying and understanding how polymorphisms in the SCARB1 gene or other genes related to lipid metabolism impact human physiology is essential and will play a major role in the development of personalized medicine for improved diagnosis and treatment of infertility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.