ReviewBiology of reproduction2014
The role of placental nutrient sensing in maternal-fetal resource allocation.
Review in Biology of reproduction, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 1 synthesis or guideline pooled it, 152 citations in OpenAlex.
- Gestational reactive hypoglycaemia and adverse pregnancy outcomes: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Maternal Diet Quality Is Associated with Placental Proteins in the Placental Insulin/Growth Factor, Environmental Stress, Inflammation, and mTOR Signaling Pathways: The Healthy Start ECHO Cohort.The Journal of nutrition · 2022Trial
- Effect of type 2 diabetes mellitus on placental expression and activity of nutrient transporters and their association with birth weight and neonatal adiposity.Molecular and cellular endocrinology · 2021Trial
- Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care.Physiological reviews · 2026Review
- Combined EP300 and CREBBP Expression Levels Regulate Human Trophoblast Differentiation.International journal of molecular sciences · 2026Article
- Bernard was right about the placenta.The Journal of physiology · 2026Article
- Relationship Between Pre-Pregnancy Body Mass Index, Gestational Weight Gain, and Perinatal Outcomes Among Women Delivering at a General Hospital, Nakhon Si Thammarat Province.International journal of environmental research and public health · 2026Article
- Gestational Diabetes Mellitus, Glycemic Management Trajectories, and Offspring Growth Patterns and Obesity Risk.Diabetes care · 2026Article
- Metabolic control of feto-placental development and pregnancy outcomes.Nature reviews. Endocrinology · 2026Review
- Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences.Cells · 2026Review
- Placental Protein Release and Uptake From the Fetal Circulation in Healthy Term Pregnancies-A Human In Vivo Exploratory Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- The Placenta in Gestational Diabetes: An Integrated Review on Metabolic Pathways, Genetic, Epigenetic and Ultrasound Biomarkers for Clinical Perspectives.International journal of molecular sciences · 2026Review
- Excess folic acid disrupts placental endocrine functionFrontiers in nutrition · 2026Article
- Mitochondrial dysfunction and immune microenvironment in gestational diabetes mellitus: insights from bioinformatics analysis and experimental validation.Frontiers in immunology · 2026Article
- Maternal Nutritional Status Governs Fetal Development by Modulating Imprinting Gene GAB1-Mediated Trophoblast Differentiation in the Placenta.Cell proliferation · 2025Article
- The energy resistance principle.Cell metabolism · 2025Review
- Multi-omic integration reveals dynamic changes in human placental metabolism across gestation.bioRxiv : the preprint server for biology · 2025Article
- Maternal BMI and Diet Quality Modulate Pregnancy Oxidative and Inflammatory Homeostasis.Nutrients · 2025Observational
- A method for dyadic cardiac rhythmicity analysis: Preliminary evidence on bilateral interactions in fetal-maternal cardiac dynamics.Experimental physiology · 2025Article
- Placental Metabolism Is Linked to Prenatal Vitamin Supplement Use in the First Month of Pregnancy in the MARBLES Cohort.The Journal of nutrition · 2025Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The placenta mediates maternal-fetal exchange and has historically been regarded as a passive conduit for nutrients. However, emerging evidence suggests that the placenta actively responds to nutritional and metabolic signals from the mother and the fetus. We propose that the placenta integrates a multitude of maternal and fetal nutritional cues with information from intrinsic nutrient-sensing signaling pathways to match fetal demand with maternal supply by regulating maternal physiology, placental growth, and nutrient transport. This process, which we have called placental nutrient sensing, ensures optimal allocation of resources between the mother and the fetus to maximize the chances for propagation of parental genes without jeopardizing maternal health. We suggest that these mechanisms have evolved because of the evolutionary pressures of maternal undernutrition, which result in decreased placental growth and down-regulation of nutrient transporters, thereby limiting fetal growth to ensure maternal survival. These regulatory loops may also function in response to maternal overnutrition, leading to increased placental growth and nutrient transport in cases of maternal obesity or gestational diabetes. Thus, placental nutrient sensing modulates maternal-fetal resource allocation to increase the likelihood of reproductive success. This model implies that the placenta plays a critical role in mediating fetal programming and determining lifelong health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.