ArticlePloS one2014
Genome-wide association analysis of radiation resistance in Drosophila melanogaster.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- NATURAL VARIATION IN RADIOTOLERANCE IS ASSOCIATED WITH DIFFERENCES IN INNATE IMMUNE ACTIVITY AND S-PHASE TRANSCRIPTION IN DROSOPHILA MELANOGASTER.bioRxiv : the preprint server for biology · 2026Article
- Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations.PLoS genetics · 2026Article
- Drosophila melanogaster: an old and future ally to radiobiology.Journal of radiation research · 2025Review
- Cosmopolitan inversions have a major impact on trait variation and the power of different GWAS approaches to identify associations.bioRxiv : the preprint server for biology · 2025Article
- DNA repair in tumor radioresistance: insights from fruit flies genetics.Cellular oncology (Dordrecht, Netherlands) · 2024Review
- The genetic basis of adaptation to copper pollution inFrontiers in genetics · 2023Article
- Identification of Novel Regulators of Radiosensitivity Using High-Throughput Genetic Screening.International journal of molecular sciences · 2022Review
- Article
- Proteomics Reveals Distinct Changes Associated with Increased Gamma Radiation Resistance in the Black YeastGenes · 2020Article
- Anther-smut fungi from more contaminated sites in Chernobyl show lower infection ability and lower viability following experimental irradiation.Ecology and evolution · 2020Article
- Toxicological Study and Genetic Basis of BTEX Susceptibility inFrontiers in genetics · 2020Article
- Genome-Wide Association Analysis of Anoxia Tolerance inG3 (Bethesda, Md.) · 2019Article
- Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster.Behavior genetics · 2019Article
- The Sleep Inbred Panel, a Collection of InbredG3 (Bethesda, Md.) · 2018Article
- Article
- The road less traveled: from genotype to phenotype in flies and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Charting the genotype-phenotype map: lessons from the Drosophila melanogaster Genetic Reference Panel.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- The Nature, Extent, and Consequences of Genetic Variation in the opa Repeats of Notch in Drosophila.G3 (Bethesda, Md.) · 2015Article
- A Drosophila model to investigate the neurotoxic side effects of radiation exposure.Disease models & mechanisms · 2015Article
- Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes.PloS one · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIonizing radiation is genotoxic to cells. Healthy tissue toxicity in patients and radiation resistance in tumors present common clinical challenges in delivering effective radiation therapies. Radiation response is a complex, polygenic trait with unknown genetic determinants. The Drosophila Genetic Reference Panel (DGRP) provides a model to investigate the genetics of natural variation for sensitivity to radiation. METHODS AND
findingsRadiation response was quantified in 154 inbred DGRP lines, among which 92 radiosensitive lines and 62 radioresistant lines were classified as controls and cases, respectively. A case-control genome-wide association screen for radioresistance was performed. There are 32 single nucleotide polymorphisms (SNPs) associated with radio resistance at a nominal p<10(-5); all had modest effect sizes and were common variants with the minor allele frequency >5%. All the genes implicated by those SNP hits were novel, many without a known role in radiation resistance and some with unknown function. Variants in known DNA damage and repair genes associated with radiation response were below the significance threshold of p<10(-5) and were not present among the significant hits. No SNP met the genome-wide significance threshold (p = 1.49 × 10(-7)), indicating a necessity for a larger sample size.
conclusionsSeveral genes not previously associated with variation in radiation resistance were identified. These genes, especially the ones with human homologs, form the basis for exploring new pathways involved in radiation resistance in novel functional studies. An improved DGRP model with a sample size of at least 265 lines and ideally up to 793 lines is recommended for future studies of complex traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.