ReviewCell host & microbe2014
Collateral damage: microbiota-derived metabolites and immune function in the antibiotic era.
Review in Cell host & microbe, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Fecal microbiota transplantation ameliorates radiation-induced lung injury by reshaping gut metabolic homeostasis to activate FAM134B-mediated ER-phagy.PLoS pathogens · 2026Article
- Structural-activity relationship ofFrontiers in immunology · 2026Review
- In Vitro Gastrointestinal Digestion ofNutrients · 2025Article
- The potential mechanism of action of gut flora and bile acids through the TGR5/TRPV1 signaling pathway in diabetic peripheral neuropathic pain.Frontiers in endocrinology · 2024Review
- Prospecting Microbial Genomes for Biomolecules and Their Applications.Indian journal of microbiology · 2022Review
- Butyrate administration is not sufficient to improve immune reconstitution in antiretroviral-treated SIV-infected macaques.Scientific reports · 2022Article
- Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management.Frontiers in nutrition · 2022Review
- Microbiome Studies in Non-human Primates.Current HIV/AIDS reports · 2021Review
- Comparison of gut microbiota in autism spectrum disorders and neurotypical boys in China: A case-control study.Synthetic and systems biotechnology · 2021Article
- Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli.Nature microbiology · 2020Article
- Genetic and Biochemical Analysis of Anaerobic Respiration in Bacteroides fragilis and Its ImportancemBio · 2020Article
- B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids.Nature communications · 2020Article
- Overuse of antianaerobic drug is associated with poor postchemotherapy prognosis of patients with hepatocellular carcinoma.International journal of cancer · 2019Article
- Early airway microbial metagenomic and metabolomic signatures are associated with development of severe bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Gut microbiomes and their metabolites shape human and animal health.Journal of microbiology (Seoul, Korea) · 2018Article
- Targeting friend and foe: Emerging therapeutics in the age of gut microbiome and disease.Journal of microbiology (Seoul, Korea) · 2018Review
- The germ-organ theory of non-communicable diseases.Nature reviews. Microbiology · 2018Review
- Assessing gut microbiota perturbations during the early phase of infectious diarrhea in Vietnamese children.Gut microbes · 2018Article
- Understanding physician antibiotic prescribing behavior for children with enterovirus infection.PloS one · 2018Article
- Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice.Theranostics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Our long-standing evolutionary association with gut-associated microbial communities has given rise to an intimate relationship, which affects many aspects of human health. Recent studies on the mechanisms that link these microbial communities to immune education, nutrition, and protection against pathogens point to microbiota-derived metabolites as key players during these microbe-host interactions. A disruption of gut-associated microbial communities by antibiotic treatment can result in a depletion of microbiota-derived metabolites, thereby enhancing pathogen susceptibility, impairing immune homeostasis, and contributing to the rise of certain chronic inflammatory diseases. Here, we highlight some of the recently elucidated mechanisms that showcase the impacts of microbiota-derived metabolites on human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.