Evidence map›Paper›PMID 25121741›Full record

ArticleCell host & microbe2014

What lies within: coinfections and immunity.

Blossom Damania, Dirk P Dittmer

Open access · bronzeAbstract readComment
In one paragraph

Article in Cell host & microbe, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Altered purinergic P2X7 and ABiomedical journal · 2024
    Article
  4. The outcomes of polyparasitism in stray cats from Brazilian Midwest assessed by epidemiological, hematological and pathological data.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Blossom DamaniaDepartment of Microbiology and Immunology, Program in Global Oncology at the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA.
Dirk P DittmerDepartment of Microbiology and Immunology, Program in Global Oncology at the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA. Electronic address: ddittmer@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Vironomics and Biostatistics CoreP01CA019014 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BLOSSOM A DAMANIA, NANCY JOAN RAAB-TRAUB · 1985 to 2026
$43.8M
Proteomics Pathway DiscoveryU19AI109965 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DUNCAN, JOSEPH A · 2014 to 2018
$14.9M
Innate Immunity and KSHVR01DE018281 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A · 2007 to 2016
$3.5M
NCI NIH HHS CA019014NCI NIH HHS P01 CA019014NIAID NIH HHS AI109965NIAID NIH HHS U19 AI109965NIDCR NIH HHS DE018281NIDCR NIH HHS R01 DE018281
6 · The paper itself

Abstract

Helminth-induced immunomodulation is thought to influence the outcome of secondary infections. Osborne et al. (2014) and Reese et al. (2014) demonstrate that helminth infection impacts viral infections by tilting the immune system toward Th2/M2 immune regulatory responses that dampen Th1/M1 antiviral responses as well as promote reactivation of latent herpesviruses.

Indexed as

ImmunomodulationAnimalsbeta-N-AcetylhexosaminidasesCaliciviridae InfectionsCoinfectionGammaherpesvirinaeGastroenteritisHerpesvirus 8, HumanHumansInterferon-gammaInterleukin-4LectinsMicrobiotaNorovirusSchistosoma mansoniSchistosomiasis mansonibeta-N-AcetylhexosaminidasesInterferon-gammaInterleukin-4LectinsSTAT6 Transcription Factor

Identifiers

PMID25121741
PMCPMC4135381
OpenAlexW1966438069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.