ArticleJournal of the Royal Society, Interface2014
An explicit immunogenetic model of gastrointestinal nematode infection in sheep.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Modelling the Transmission Dynamics and Risk of Ovine Cystic Echinococcosis in Argentina Using the CEST Model (Cystic Echinococcosis Stochastic Transmission Model).Journal of parasitology research · 2026Article
- Modelling the risk of food-borne transmission ofEpidemiology and infection · 2025Article
- Inferring the energy cost of resistance to parasitic infection and its link to a trade-off.BMC ecology and evolution · 2025Article
- Secretory IgA as Biomarker for Gastrointestinal Nematodes Natural Infection in Different Breed Sheep.Animals : an open access journal from MDPI · 2023Article
- Quantifying Spillover Risk with an Integrated Bat-Rabies Dynamic Modeling Framework.Transboundary and emerging diseases · 2023Article
- Bovine Natural Antibody Relationships to Specific Antibodies andVeterinary sciences · 2022Article
- Within-host mechanisms of immune regulation explain the contrasting dynamics of two helminth species in both single and dual infections.PLoS computational biology · 2020Article
- External disturbances impact helminth-host interactions by affecting dynamics of infection, parasite traits, and host immune responses.Ecology and evolution · 2019Article
- The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep (Ovis aries).PLoS genetics · 2019Article
- Immunity to gastrointestinal nematodes in ruminants: effector cell mechanisms and cytokines.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Review
- A simulation model to investigate interactions between first season grazing calves and Ostertagia ostertagi.Veterinary parasitology · 2016Article
- The control of sea lice in Atlantic salmon by selective breeding.Journal of the Royal Society, Interface · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Gastrointestinal nematodes are a global cause of disease and death in humans, wildlife and livestock. Livestock infection has historically been controlled with anthelmintic drugs, but the development of resistance means that alternative controls are needed. The most promising alternatives are vaccination, nutritional supplementation and selective breeding, all of which act by enhancing the immune response. Currently, control planning is hampered by reliance on the faecal egg count (FEC), which suffers from low accuracy and a nonlinear and indirect relationship with infection intensity and host immune responses. We address this gap by using extensive parasitological, immunological and genetic data on the sheep-Teladorsagia circumcincta interaction to create an immunologically explicit model of infection dynamics in a sheep flock that links host genetic variation with variation in the two key immune responses to predict the observed parasitological measures. Using our model, we show that the immune responses are highly heritable and by comparing selective breeding based on low FECs versus high plasma IgA responses, we show that the immune markers are a much improved measure of host resistance. In summary, we have created a model of host-parasite infections that explicitly captures the development of the adaptive immune response and show that by integrating genetic, immunological and parasitological understanding we can identify new immune-based markers for diagnosis and control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.