ArticlePLoS genetics2014
An otx/nodal regulatory signature for posterior neural development in ascidians.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Conservation ofCells · 2024Article
- Ascidian embryonic cells with properties of neural-crest cells and neuromesodermal progenitors of vertebrates.Nature ecology & evolution · 2024Article
- Molecular control of cellulosic fin morphogenesis in ascidians.BMC biology · 2024Article
- Article
- Article
- Single-cell analysis of cell fate bifurcation in the chordate Ciona.BMC biology · 2021Article
- Ciona Brachyury proximal and distal enhancers have different FGF dose-response relationships.PLoS genetics · 2021Article
- Conservation of peripheral nervous system formation mechanisms in divergent ascidian embryos.eLife · 2020Article
- Inferring Tunicate Relationships and the Evolution of the Tunicate Hox Cluster with the Genome of Corella inflata.Genome biology and evolution · 2020Article
- Regulation of Neurogenesis by FGF Signaling and Neurogenin in the Invertebrate ChordateFrontiers in cell and developmental biology · 2020Article
- Differential Expression of a Classic Cadherin Directs Tissue-Level Contractile Asymmetry during Neural Tube Closure.Developmental cell · 2019Article
- Antero-posterior ectoderm patterning by canonical Wnt signaling during ascidian development.PLoS genetics · 2019Article
- Article
- Dynamic interplay of cell fate, polarity and force generation in ascidian embryos.Current opinion in genetics & development · 2018Review
- Article
- ANISEED 2017: extending the integrated ascidian database to the exploration and evolutionary comparison of genome-scale datasets.Nucleic acids research · 2018Article
- Nodal/Activin Pathway is a Conserved Neural Induction Signal in Chordates.Nature ecology & evolution · 2017Article
- Genetic pathways for differentiation of the peripheral nervous system in ascidians.Nature communications · 2015Article
- Tunicates: exploring the sea shores and roaming the open ocean. A tribute to Thomas Huxley.Open biology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In chordates, neural induction is the first step of a complex developmental process through which ectodermal cells acquire a neural identity. In ascidians, FGF-mediated neural induction occurs at the 32-cell stage in two blastomere pairs, precursors respectively of anterior and posterior neural tissue. We combined molecular embryology and cis-regulatory analysis to unveil in the ascidian Ciona intestinalis the remarkably simple proximal genetic network that controls posterior neural fate acquisition downstream of FGF. We report that the combined action of two direct FGF targets, the TGFβ factor Nodal, acting via Smad- and Fox-binding sites, and the transcription factor Otx suffices to trigger ascidian posterior neural tissue formation. Moreover, we found that this strategy is conserved in the distantly related ascidian Phallusia mammillata, in spite of extreme sequence divergence in the cis-regulatory sequences involved. Our results thus highlight that the modes of gene regulatory network evolution differ with the evolutionary scale considered. Within ascidians, developmental regulatory networks are remarkably robust to genome sequence divergence. Between ascidians and vertebrates, major fate determinants, such as Otx and Nodal, can be co-opted into different networks. Comparative developmental studies in ascidians with divergent genomes will thus uncover shared ascidian strategies, and contribute to a better understanding of the diversity of developmental strategies within chordates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.