Evidence map›Paper›PMID 25121549›Full record

ArticleThe Journal of general virology2014

Novel porcine-like human G26P[19] rotavirus identified in hospitalized paediatric diarrhoea patients in Ho Chi Minh City, Vietnam.

Phan Vu Tra My, Maia A Rabaa, Celeste Donato, Daniel Cowley, Voong Vinh Phat, Tran Thi Ngoc Dung, Pham Hong Anh, Ha Vinh, Juliet E Bryant, Paul Kellam and 4 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of general virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Phan Vu Tra MyThe Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Maia A RabaaCentre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, UK.
Celeste DonatoLa Trobe University, Melbourne, Australia.
Daniel CowleyMurdoch Childrens Research Institute, Melbourne, Australia.
Voong Vinh PhatThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Tran Thi Ngoc DungThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Pham Hong AnhThe Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Ha VinhThe Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Juliet E BryantWellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Hanoi, Vietnam.
Paul KellamDivision of Infection and Immunity, University College London, London, United Kingdom.
Guy ThwaitesCentre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK.
Mark E J WoolhouseCentre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, UK.
Carl D KirkwoodLa Trobe University, Melbourne, Australia.
Stephen BakerThe London School of Hygiene and Tropical Medicine, London, UK.
Oxford University Clinical Research Unit · VNHospital for Tropical Diseases · VNMurdoch Children's Research Institute · AUCentre for Immunity, Infection and Evolution · GBLa Trobe University · AUNuffield Orthopaedic Centre · GBUniversity College London · GBUniversity of Edinburgh · GB

Funding

Wellcome Trust 089276/2/09/2Wellcome Trust 095831Wellcome Trust 100087Wellcome Trust 100087/Z/12/ZWellcome Trust WT/093724/Z/10/Z
6 · The paper itself

Abstract

During a hospital-based diarrhoeal disease study conducted in Ho Chi Minh City, Vietnam from 2009 to 2010, we identified four symptomatic children infected with G26P[19] rotavirus (RV)--an atypical variant that has not previously been reported in human gastroenteritis. To determine the genetic structure and investigate the origin of this G26P[19] strain, the whole genome of a representative example was characterized, revealing a novel genome constellation: G26-P[19]-I5-R1-C1-M1-A8-N1-T1-E1-H1. The genome segments were most closely related to porcine (VP7, VP4, VP6 and NSP1) and Wa-like porcine RVs (VP1-3 and NSP2-5). We proposed that this G26P[19] strain was the product of zoonotic transmission coupled with one or more reassortment events occurring in human and/or animal reservoirs. The identification of such strains has potential implications for vaccine efficacy in south-east Asia, and outlines the utility of whole-genome sequencing for studying RV diversity and zoonotic potential during disease surveillance.

Indexed as

Child, PreschoolDiarrheaGenotypeHumansInpatientsMolecular Sequence DataPhylogenyRotavirusRotavirus InfectionsVietnam

Identifiers

PMID25121549
PMCPMC4233630
OpenAlexW2115545981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.