ArticlePLoS computational biology2014
The protective role of symmetric stem cell division on the accumulation of heritable damage.
Article in PLoS computational biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Asymmetric division sustains stem cell heterogeneity in the Drosophila testicular niche.Communications biology · 2026Article
- Asymmetric stem cell division maintains genetic heterogeneity of tissue cells.bioRxiv : the preprint server for biology · 2024Article
- Does Shoot Apical Meristem Function as the Germline in Safeguarding Against Excess of Mutations?Frontiers in plant science · 2021Review
- Modelling stem cell ageing: a multi-compartment continuum approach.Royal Society open science · 2020Article
- Exploring immuno-regulatory mechanisms in the tumor microenvironment: Model and design of protocols for cancer remission.PloS one · 2018Article
- CCAT1 stimulation of the symmetric division of NSCLC stem cells through activation of the Wnt signalling cascade.Gene therapy · 2018Article
- Mathematical models of cell phenotype regulation and reprogramming: Make cancer cells sensitive again!Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Mathematical models of tissue stem and transit target cell divisions and the risk of radiation- or smoking-associated cancer.PLoS computational biology · 2017Article
- Cell dynamics in tumour environment after treatments.Journal of the Royal Society, Interface · 2017Article
- The role of backward cell migration in two-hit mutants' production in the stem cell niche.PloS one · 2017Article
- The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts.Biology direct · 2016Article
- A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer.Cell stem cell · 2016Article
- Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaques.BMC biology · 2015Article
- Fixation times in differentiation and evolution in the presence of bottlenecks, deserts, and oases.Journal of theoretical biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Stem cell divisions are either asymmetric-in which one daughter cell remains a stem cell and one does not-or symmetric, in which both daughter cells adopt the same fate, either stem or non-stem. Recent studies show that in many tissues operating under homeostatic conditions stem cell division patterns are strongly biased toward the symmetric outcome, raising the question of whether symmetry confers some benefit. Here, we show that symmetry, via extinction of damaged stem-cell clones, reduces the lifetime risk of accumulating phenotypically silent heritable damage (mutations or aberrant epigenetic changes) in individual stem cells. This effect is greatest in rapidly cycling tissues subject to accelerating rates of damage accumulation over time, a scenario that describes the progression of many cancers. A decrease in the rate of cellular damage accumulation may be an important factor favoring symmetric patterns of stem cell division.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.