Evidence map›Paper›PMID 25121131›Full record

ArticleTheScientificWorldJournal2014

Sequence variants of ADIPOQ and association with type 2 diabetes mellitus in Taiwan Chinese Han population.

Ming-Kai Tsai, Hui-Min David Wang, Jeng-Chuan Shiang, I-Hung Chen, Chih-Chiang Wang, Ya-Fen Shiao, Wen-Sheng Liu, Tai-Jung Lin, Tsung-Ming Chen, Ya-Huey Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  7. Effect of Genetic Variations in theDiabetes, metabolic syndrome and obesity : targets and therapy · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Ming-Kai TsaiDivision of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
Hui-Min David WangDepartment of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Jeng-Chuan ShiangDivision of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
I-Hung ChenDivision of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
Chih-Chiang WangDivision of Nephrology, Department of Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
Ya-Fen ShiaoAsia-Pacific Biotech Developing, Inc., Kaohsiung 80681, Taiwan.
Wen-Sheng LiuAsia-Pacific Biotech Developing, Inc., Kaohsiung 80681, Taiwan.
Tai-Jung LinDepartment of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 90741, Taiwan.
Tsung-Ming ChenDepartment of Physiology, College of Medicine, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan ; Department and Graduate Institute of Aquaculture, National Kaohsiung Marine University, Kaohsiung 81157, Taiwan.
Ya-Huey ChenCenter for Molecular Medicine, China Medical University Hospital, Taichung 40477, Taiwan ; Graduate Institute of Cancer Biology, China Medical University, Cancer Center Building 8F, No. 6 Hsueh-Shih Road, Taichung 40477, Taiwan.
Kaohsiung Armed Forces General Hospital · TWChina Medical University · TWKaohsiung Medical University · TWNational Cheng Kung University · TWTajen University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes is a serious global health problem. Large-scale genome-wide association studies identified loci for type 2 diabetes mellitus (T2DM), including adiponectin (ADIPOQ) gene and transcription factor 7-like 2 (TCF7L2), but few studies clarified the effect of genetic polymorphisms of ADIPOQ and TCF7L2 on risk of T2DM. We attempted to elucidate association between T2DM and polymorphic variations of both in Taiwan's Chinese Han population, with our retrospective case-control study genotyping single nucleotide polymorphisms (SNPs) in ADIPOQ and TCF7L2 genes both in 149 T2DM patients and in 139 healthy controls from Taiwan. Statistical analysis gauged association of these polymorphisms with risk of T2DM to show ADIPOQ rs1501299 polymorphism variations strongly correlated with T2DM risk (P = 0.042), with rs2241766 polymorphism being not associated with T2DM (P = 0.967). However, both polymorphisms rs7903146 and rs12255372 of TCF7L2 were rarely detected in Taiwanese people. This study avers that ADIPOQ rs1501299 polymorphism contributes to risk of T2DM in the Taiwanese population.

Indexed as

AdiponectinAsian PeopleDiabetes Mellitus, Type 2Genome-Wide Association StudyHumansOdds RatioPolymorphism, Single NucleotideRetrospective StudiesTaiwanTranscription Factor 7-Like 2 ProteinAdiponectinADIPOQ protein, humanTCF7L2 protein, humanTranscription Factor 7-Like 2 Protein

Identifiers

PMID25121131
PMCPMC4121223
OpenAlexW2006561253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.