Evidence map›Paper›PMID 25120998›Full record

ArticleJournal of clinical and diagnostic research : JCDR2014

Beneficial effects of nebivolol in comparison with atenolol on safety and tolerability in essential hypertension.

Vivek V Bhosale, S C Inamdar, Karande V B, Burute S R, Murthy M B, Ghatak A

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Vivek V BhosaleScientist, Clinical and Experimental Medicine, CSIR-Central Drug Research Institute , Lucknow, India .
S C InamdarAssociate Professor, Department of Pharmacology, Government Medical College , Miraj, Maharashtra, India .
Karande V BLecturer, Department of Pharmacology, Government Medical College , Miraj, Maharashtra, India .
Burute S RLecturer, Department of Pharmacology, Government Medical College , Miraj, Maharashtra, India .
Murthy M BLecturer, Department of Pharmacology, Government Medical College , Miraj, Maharashtra, India .
Ghatak AChief Scientist, Clinical and Experimental Meidcine, CSIR-Central Drug Research Institute , Lucknow, India .
Central Drug Research Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHypertension, "The silent killer" is a multifactorial disorder which is asymptomatic and if left untreated leads to lethal complications. Nebivolol is a third generation beta blocker with additional vasodilating property due to nitric oxide release.

aimThe current study aims to assess efficacy and safety of Nebivolol and compare with Atenolol.

methodsThis was prospective, double blind, comparative controlled clinical study. Total 90 patients were enrolled into study as per selection criteria. Patients were randomized to receive Atenolol and Nebivolol with 45 patients in each group for 12 weeks. RESULTS AND

conclusionThe mean reduction diastolic blood pressure in Nebivolol and Atenolol group was 10.77±2.60 and 10.05±2.83 respectively. The number of patients with adverse effect events was higher in the Atenolol than in the Nebivolol group (36.84% of Atenolol Vs 12.82% of Nebivolol). Thus it can be concluded that, for the same antihypertensive effect, Nebivolol was better tolerated than Atenolol.

Indexed as

AtenololHypertensionNebivolol

Identifiers

PMID25120998
PMCPMC4129321
OpenAlexW1982610801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.