Evidence map›Paper›PMID 25120928›Full record

ArticlePulmonary medicine2014

Effects of inactivated Bordetella pertussis on phosphodiesterase in the lung of ovalbumin sensitized and challenged rats.

Ya-Juan Wang, Shun-De Song, Jun-Chun Chen, Xue-Feng Wang, Ya-Li Jiang, Qiang-Min Xie, Ji-Qiang Chen, Zi-Gang Li, Hui-Fang Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Ya-Juan WangZhejiang Respiratory Drugs Research Laboratory of SFDA of China, School of Medicine, Zhejiang University, Hangzhou 310058, China ; Clinical College of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, China.
Shun-De SongZhejiang Respiratory Drugs Research Laboratory of SFDA of China, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Jun-Chun ChenFirst Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou 310000, China.
Xue-Feng WangSecond Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310005, China.
Ya-Li JiangZhejiang Respiratory Drugs Research Laboratory of SFDA of China, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Qiang-Min XieZhejiang Respiratory Drugs Research Laboratory of SFDA of China, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Ji-Qiang ChenZhejiang Respiratory Drugs Research Laboratory of SFDA of China, School of Medicine, Zhejiang University, Hangzhou 310058, China.
Zi-Gang LiWomen's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Hui-Fang TangZhejiang Respiratory Drugs Research Laboratory of SFDA of China, School of Medicine, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-9541-1352
Zhejiang University · CNFirst Affiliated Hospital Zhejiang University · CNAnhui University of Traditional Chinese Medicine · CNWomen's Hospital, School of Medicine, Zhejiang University · CNZhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper indicated that inactivated Bordetella pertussis (iBp) can enhance the lung airway hyperreactivity of the rats sensitized and challenged with OVA. The mechanisms were involved in the upregulation of cAMP-PDE activity and PDE4A, PDE4D, and PDE3 gene expression in the lungs. But only PDE4 activity was different between the OVA and OVA+iBp groups, and PDE4D expression was significantly increased in iBp rats alone. So, our data suggested that cosensitization with OVA and iBp affects lung airway reactivity by modulating the lung cAMP-PDE activity and PDE4D gene expression.

Indexed as

3',5'-Cyclic-AMP PhosphodiesterasesAnimalsBordetella pertussisCyclic Nucleotide Phosphodiesterases, Type 3Cyclic Nucleotide Phosphodiesterases, Type 4Gene Expression RegulationLungMaleOvalbuminPertussis VaccinePhosphoric Diester HydrolasesRatsRats, Sprague-DawleyUp-RegulationVaccines, Inactivated3',5'-Cyclic-AMP PhosphodiesterasesCyclic Nucleotide Phosphodiesterases, Type 3Cyclic Nucleotide Phosphodiesterases, Type 4OvalbuminPde4a protein, ratPDE4D protein, ratPertussis VaccinePhosphoric Diester HydrolasesVaccines, Inactivated

Identifiers

PMID25120928
PMCPMC4121004
OpenAlexW1975883120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.