Evidence map›Paper›PMID 25120817›Full record

ArticleInternational journal of clinical and experimental pathology2014

Characteristics of demyelinating Charcot-Marie-Tooth disease with concurrent diabetes mellitus.

Zhiliang Yu, Xiaohua Wu, Huijun Xie, Ying Han, Yangtai Guan, Yong Qin, Huimin Zheng, Jianming Jiang, Zhenmin Niu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Dynamin deficiency causes insulin secretion failure and hyperglycemia.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zhiliang YuDepartment of Neurology, Shanghai Seventh People's Hospital Shanghai, China ; Department of Neurology, Changhai Hospital, Second Military Medical University Shanghai, China.
Xiaohua WuDepartment of Neurology, Shanghai Seventh People's Hospital Shanghai, China.
Huijun XieDepartment of Neurology, Changhai Hospital, Second Military Medical University Shanghai, China.
Ying HanDepartment of Neurology, Shanghai Seventh People's Hospital Shanghai, China.
Yangtai GuanDepartment of Neurology, Changhai Hospital, Second Military Medical University Shanghai, China.
Yong QinDepartment of Neurology, Shanghai Seventh People's Hospital Shanghai, China.
Huimin ZhengDepartment of Neurology, Changhai Hospital, Second Military Medical University Shanghai, China.
Jianming JiangDepartment of Neurology, Changhai Hospital, Second Military Medical University Shanghai, China.
Zhenmin NiuChinese National Human Genome Center at Shanghai Shanghai, China.
Second Military Medical University · CNSeventh People's Hospital of Shanghai · CNChinese National Human Genome Center at Shanghai · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCharcot-Marie-Tooth disease (CMT) is the most common type of inherited peripheral neuropathy and has a high degree of genetic heterogeneity. CMT with concurrent diabetes mellitus (DM) is rare. The purpose of this study is to explore the genetic, clinical and pathological characteristics of the patients with CMT and concurrent DM.

methodsWe investigated gene mutations (the peripheral myelin protein 22 gene, myelin protein zero gene, lipopolysaccharide-induced tumor necrosis factor-α factor gene, early growth response gene and the neurofilament light chain gene loci) of a relatively large and typical Chinese family with CMT1 and concurrent DM2. From the literature, we also retrieved all reported families and single cases with CMT and concurrent DM. We comprehensively analyzed the characteristics of total 33 patients with CMT and concurrent DM, and further compared these characteristics with those of patients of diabetic peripheral neuropathy (DPN).

resultsPatients with CMT and concurrent DM had some relatively independent characteristics and pathogenic mechanisms. So we designated that kind of characteristic demyelinating CMT which accompanies DM as Yu-Xie syndrome (YXS), a new specific clinical subtype of CMT.

conclusionCMT is an etiologic factor of DM, even though the intrinsic association between CMT and DM still remains further exploration.

Indexed as

AdultCharcot-Marie-Tooth DiseaseChinaDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedMutationPedigreePolymerase Chain ReactionCharcot-Marie-Tooth diseasediabetes mellituspedigree analysisYu-Xie syndrome

Identifiers

PMID25120817
PMCPMC4129052
OpenAlexW142520276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.