ArticleInternational journal of clinical and experimental pathology2014
Different levels of circulating Th22 cell and its related molecules in Graves' disease and Hashimoto's thyroiditis.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Th17-associated cytokine gene hypomethylation reflects epigenetic dysregulation in graves' disease.Frontiers in immunology · 2025Article
- The mJournal of inflammation research · 2025Review
- Effect of methimazole treatment on Th1, Th17, and Th22 lymphocytes in pediatric Graves' disease patients.Frontiers in immunology · 2024Article
- Comprehensive immunophenotypic analysis reveals the pathological involvement of Th17 cells in Graves' disease.Scientific reports · 2022Article
- Plasma levels of Th17-associated cytokines and selenium status in autoimmune thyroid diseases.Immunity, inflammation and disease · 2021Article
- METTL3 gene polymorphisms contribute to susceptibility to autoimmune thyroid disease.Endocrine · 2021Article
- Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases.Frontiers in immunology · 2021Review
- Epigenetic Regulations of AhR in the Aspect of Immunomodulation.International journal of molecular sciences · 2020Review
- Elevated Interleukin-36α And CD4Frontiers in endocrinology · 2018Article
- Role of the T and B lymphocytes in pathogenesis of autoimmune thyroid diseases.Thyroid research · 2018Article
- Article
- Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease.International journal of endocrinology · 2017Article
- The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases.Frontiers in immunology · 2017Review
- STAT6 deficiency ameliorates Graves' disease severity by suppressing thyroid epithelial cell hyperplasia.Cell death & disease · 2016Article
- The Effects of IL-22 on the Inflammatory Mediator Production, Proliferation, and Barrier Function of HUVECs.Inflammation · 2016Article
- Review
- Vitamin D and chronic hepatitis C: effects on success rate and prevention of side effects associated with pegylated interferon-α and ribavirin.International journal of clinical and experimental medicine · 2015Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to make a comparative analysis of the possible different expression of Th22 cells in two subtypes of autoimmune thyroid diseases (AITDs), i.e., Graves' disease (GD) and Hashimoto's thyroiditis (HT).
methodsWe recruited 61 AITDs patients (31 GD and 30 HT) and 22 controls. Serum level of IL-22 was measured by enzyme linked immunosorbent assay (ELISA). The proportion of Th22 cells in peripheral blood mononuclear cells (PBMCs) was analyzed by flow cytometry. The messenger RNA (mRNA) expressions of IL-22, its receptors (IL10R2, IL22R1) and key transcription factor (aryl hydrocarbon receptor, AHR) in PBMCs were assayed by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Several cytokines of the cultured PBMCs were also measured under IL-22 stimulation.
resultsThe proportion of Th22 cells, serum IL22 level and IL-22 mRNA expression were significantly higher in patients with GD than in healthy controls. Additionally, AHR increased in GD patients compared to healthy controls. However, the elevation of Th22 cells and their relative cytokines was not found in patients with HT. Consistent with specific mRNAs expression of cultured PBMCs, IL-4 increment in supernatant was much higher in GD group than in control group, while IFN-γ levels were decreased under IL-22 stimulation.
conclusionTh22 cells may participate in the pathogenesis of AITDs as a proinflammatory factor, especially in GD, through expressing and secreting IL-22.
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Identifiers
25120780PMC4129015W227671759What OpenQuestion holds
Registered trials
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