ArticleInternational journal of clinical and experimental pathology2014
Nuclear localizaiton of β-catenin is associated with poor survival and chemo-/radioresistance in human cervical squamous cell cancer.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Wnt signaling and tumors (Review).Molecular and clinical oncology · 2024Review
- The immunolocalization of cadherins and beta-catenin in the cervix and vagina of cycling cows.Veterinary research communications · 2023Article
- Correlation of signal transducer and activator of transcription-3 andThe Journal of international medical research · 2023Article
- Role of immunohistochemistry in the diagnosis and staging of cutaneous squamous-cell carcinomas (Review).Experimental and therapeutic medicine · 2022Review
- β-Catenin immunocytochemical reactivity in cervicovaginal smears during regular menstrual cycles.Asian biomedicine : research, reviews and news · 2020Article
- β-Catenin: oncogenic role and therapeutic target in cervical cancer.Biological research · 2020Review
- Effects of cisplatin on the proliferation, invasion and apoptosis of breast cancer cells following β‑catenin silencing.International journal of molecular medicine · 2020Article
- Article
- ALDHFrontiers in oncology · 2020Article
- FAT1 inhibits the proliferation and metastasis of cervical cancer cells by binding β-catenin.International journal of clinical and experimental pathology · 2019Article
- Activation of Wnt-β-catenin pathway in basal-parabasal layers of normal cervical epithelium comparable during development of uterine cervical carcinoma.Molecular and cellular biochemistry · 2018Article
- Biomarkers could facilitate prediction of worse clinical outcome of cancer with special insight to cervical cancer.Contemporary oncology (Poznan, Poland) · 2018Review
- Identification of genes associated with SiHa cell sensitivity to paclitaxel by CRISPR-Cas9 knockout screening.International journal of clinical and experimental pathology · 2018Article
- Wnt signaling in cervical cancer?Journal of Cancer · 2018Review
- 'Lnc'-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling.British journal of pharmacology · 2017Review
- Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation.Molecular cancer · 2017Review
- Suppression Of β-catenin Nuclear Translocation By CGP57380 Decelerates Poor Progression And Potentiates Radiation-Induced Apoptosis in Nasopharyngeal Carcinoma.Theranostics · 2017Article
- Prognostic impact of the expression of Wnt-signaling proteins in cervical carcinoma FIGO stage I-IV treated with radiotherapy or chemoradiotherapy.Oncotarget · 2016Article
- Identification of novel NRAGE involved in the radioresistance of esophageal cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Overexpression of β-Catenin Induces Cisplatin Resistance in Oral Squamous Cell Carcinoma.BioMed research international · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear expression of β-catenin has been suggested as an independent prognostic marker in a variety of cancers. The objective of this study was to investigate the clinicopathologic significance of nuclear β-catenin expression in patients with cervical squamous cell carcinoma (CSCC). In this original research article, we detected nuclear β-catenin expression in 29/171 CSCC tissues (17.0%). Patients without nuclear β-catenin expression had a significantly better outcome than patients with nuclear β-catenin expression (93.7% versus 82.7% P = 0.027). Furthermore, nuclear β-catenin expression was predictive of prognosis in CSCC patients with early stage disease (FIGO stage I or tumor size ≤ 4 cm), with well/moderately differentiated tumors, or lymph node metastasis. Interestingly, nuclear β-catenin expression correlated with poor outcome in patients who received postoperative chemotherapy or radiotherapy. Multivariate analysis suggested that nuclear β-catenin expression is an independent prognostic indicator in CSCC. Our findings suggest that nuclear β-catenin expression may be used as a prognostic biomarker in CSCC, especially for patients with early stage disease, well/moderately differentiated tumors, or lymph node metastasis. Moreover, nuclear β-catenin expression has potential as a predictive marker of chemoresistance and radioresistance in CSCC.
Indexed as
Identifiers
25120767PMC4129002W1917344037What OpenQuestion holds
Registered trials
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