Evidence map›Paper›PMID 25120710›Full record

ArticleOncology letters2014

Icotinib inhibits the invasion of Tca8113 cells via downregulation of nuclear factor κB-mediated matrix metalloproteinase expression.

Cailing Yang, Jianguo Yan, Guoyan Yuan, Yinghua Zhang, Derong Lu, Mingxin Ren, Weigang Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Mechanisms of Invasion in Head and Neck Cancer.Archives of pathology & laboratory medicine · 2015
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cailing YangDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Xinxiang Medical University, Weihui, Henan 453100, P.R. China.
Jianguo YanDepartment of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Guoyan YuanDepartment of Neurosurgery, The First Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Yinghua ZhangDepartment of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Derong LuDepartment of Internal Digestive Medicine, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Mingxin RenDepartment of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
Weigang CuiDepartment of Human Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Icotinib is an epidermal growth factor receptor tyrosine kinase inhibitor, which has been revealed to inhibit proliferation in tumor cells. However, the effect of icotinib on cancer cell metastasis remains to be explained. This study examines the effect of icotinib on the migration and invasion of squamous cells of tongue carcinoma (Tca8113 cells)

Indexed as

icotinibmatrix metallopeptidasenuclear factor κBTca8113 cellstumor invasion

Identifiers

PMID25120710
PMCPMC4114659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.