ReviewDermatology research and practice2014
Pathogenesis of chronic urticaria: an overview.
Review in Dermatology research and practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 91 citations in OpenAlex.
- Dupilumab in Difficult-to-treat Chronic Spontaneous Urticaria: A Real-world Multicentre Cohort Study.Acta dermato-venereologica · 2026Observational
- Immune cells influence chronic spontaneous urticaria by inflammatory proteins: Mendelian randomization and bioinformatic analysis.The journal of allergy and clinical immunology. Global · 2026Article
- The effect of omalizumab treatment on inflammatory parameters in urticarial diseases: a retrospective study.Postepy dermatologii i alergologii · 2026Article
- Beyond Antihistamines: How Biologic and Small-Molecule Therapies Are Transforming Chronic Spontaneous Urticaria Care in Adults.Clinical drug investigation · 2025Review
- Minocycline-Induced Angioedema With Chronic Recurrent Urticaria Even After Drug Withdrawal: A Case Report.Cureus · 2025Article
- Case Report: Upadacitinib in the management of refractory urticarial vasculitis.Frontiers in medicine · 2025Article
- Blood Adhesion Molecules as Biomarkers in Children with Chronic Urticaria.Children (Basel, Switzerland) · 2024Article
- The antioxidant barrier, oxidative/nitrosative stress, and protein glycation in allergy: from basic research to clinical practice.Frontiers in immunology · 2024Review
- Neuro-Immuno-Psychological Aspects of Chronic Urticaria.Journal of clinical medicine · 2023Review
- Dermatologic manifestations of thyroid disease: a literature review.Frontiers in endocrinology · 2023Review
- Skin Autoimmunity Secondary to Alemtuzumab in a Tertiary Care Spanish Hospital.Neurology. Clinical practice · 2022Article
- Exacerbation of Chronic Spontaneous Urticaria Symptoms in COVID-19 Patients, Case Report.BioNanoScience · 2022Article
- Histopathology and immunophenotyping of late onset cutaneous manifestations of COVID-19 in elderly patients: Three case reports.World journal of clinical cases · 2021Article
- The efficacy and safety of herbal combination of Unani Medicine in chronic urticaria: A randomized, controlled study.Journal of traditional and complementary medicine · 2021Article
- Phosgene oxime: a highly toxic urticant and emerging chemical threat.Toxicology mechanisms and methods · 2021Review
- Behind the scenes with basophils: an emerging therapeutic target.Immunotherapy advances · 2021Review
- Chronic urticaria and thyroid pathology.The World Allergy Organization journal · 2020Article
- Does adiponectin play a role in the pathogenesis of chronic spontaneous urticaria?Central-European journal of immunology · 2020Article
- A single reaction-diffusion equation for the multifarious eruptions of urticaria.PLoS computational biology · 2020Article
- Risk factors of chronic urticaria among nurses with insomnia: A nationwide population-based study.Medicine · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of chronic urticaria is not well delineated and the treatment is palliative as it is not tied to the pathomechanism. The centrality of mast cells and their inappropriate activation and degranulation as the key pathophysiological event are well established. The triggering stimuli and the complexity of effector mechanisms remain speculative. Autoimmune origin of chronic urticaria, albeit controversial, is well documented. Numerical and behavioral alterations in basophils accompanied by changes in signaling molecule expression and function as well as aberrant activation of extrinsic pathway of coagulation are other alternative hypotheses. It is also probable that mast cells are involved in the pathogenesis through mechanisms that extend beyond high affinity IgE receptor stimulation. An increasing recognition of chronic urticaria as an immune mediated inflammatory disorder related to altered cytokine-chemokine network consequent to immune dysregulation resulting from disturbed innate immunity is emerging as yet another pathogenic explanation. It is likely that these different pathomechanisms are interlinked rather than independent cascades, acting either synergistically or sequentially to produce clinical expression of chronic urticaria. Insights into the complexities of pathogenesis may provide an impetus to develop safer, efficacious, and targeted immunomodulators and biological treatment for severe, refractory chronic urticaria.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.